{"title":"与动脉粥样硬化和炎症相关的y染色体遗传变异。","authors":"A. Lusis","doi":"10.1161/ATVBAHA.119.313369","DOIUrl":null,"url":null,"abstract":"Human GWAS (Genome-Wide Association Studies) have identified over 100 loci contributing to coronary artery disease (CAD), but such studies have largely ignored the Y chromosome (chr).1 In this issue of ATVB, Eales et al2 have identified a significant association between genetic variants on the Y chr and CAD in 129 133 men from the UK Biobank study. They followed up on this finding by identifying epigenetic and gene expression patterns associated with the variants and they present evidence that the Y chr gene ubiquitously transcribed tetratricopeptide repeat-containing Y-linked, a histone demethylase, may contribute through its inflammatory effects in macrophages.","PeriodicalId":8404,"journal":{"name":"Arteriosclerosis, Thrombosis, & Vascular Biology","volume":"23 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Y-Chromosome Genetic Variation Associated With Atherosclerosis and Inflammation.\",\"authors\":\"A. Lusis\",\"doi\":\"10.1161/ATVBAHA.119.313369\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Human GWAS (Genome-Wide Association Studies) have identified over 100 loci contributing to coronary artery disease (CAD), but such studies have largely ignored the Y chromosome (chr).1 In this issue of ATVB, Eales et al2 have identified a significant association between genetic variants on the Y chr and CAD in 129 133 men from the UK Biobank study. They followed up on this finding by identifying epigenetic and gene expression patterns associated with the variants and they present evidence that the Y chr gene ubiquitously transcribed tetratricopeptide repeat-containing Y-linked, a histone demethylase, may contribute through its inflammatory effects in macrophages.\",\"PeriodicalId\":8404,\"journal\":{\"name\":\"Arteriosclerosis, Thrombosis, & Vascular Biology\",\"volume\":\"23 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arteriosclerosis, Thrombosis, & Vascular Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1161/ATVBAHA.119.313369\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arteriosclerosis, Thrombosis, & Vascular Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1161/ATVBAHA.119.313369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Y-Chromosome Genetic Variation Associated With Atherosclerosis and Inflammation.
Human GWAS (Genome-Wide Association Studies) have identified over 100 loci contributing to coronary artery disease (CAD), but such studies have largely ignored the Y chromosome (chr).1 In this issue of ATVB, Eales et al2 have identified a significant association between genetic variants on the Y chr and CAD in 129 133 men from the UK Biobank study. They followed up on this finding by identifying epigenetic and gene expression patterns associated with the variants and they present evidence that the Y chr gene ubiquitously transcribed tetratricopeptide repeat-containing Y-linked, a histone demethylase, may contribute through its inflammatory effects in macrophages.
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