Sajid Ali, Tariq Latif, Muhammad ali, Shazia perveen, Muhammad bilal shafiq, Muhammad abu bakr
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Statistical significance was set at a p-value ≤0.05. \nResults: A total of 115 patients with a mean age of 5.42+ 1.54 years having testicular germ cell tumor were treated. Seventeen patients (14.7 %) had relapse of disease. Relapse was highest in patients with stage I disease (64.7 %). Yolk sac tumor was the most common pathology that was noted in twelve (70 %) patients. The most common site of relapse was the retroperitoneum (70 %). Age of patient, stage of disease, and lymphovascular invasion were significant predictors of relapse and survival in testicular germ cell tumors. \nConclusion: Management of patients with testicular germ cell tumors requires standardized follow-up protocol for early detection and treatment of disease relapse. Complete surgical excision with meticulous control of the residual disease is critical to prevent disease relapse. \nKeywords: Chemotherapy, Children, Outcome, Relapse, Testicular Tumor \n \n ","PeriodicalId":33701,"journal":{"name":"Journal of Islamabad Medical and Dental College","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predictors of Relapse and Survival in Testicular Germ cell Tumors in Children\",\"authors\":\"Sajid Ali, Tariq Latif, Muhammad ali, Shazia perveen, Muhammad bilal shafiq, Muhammad abu bakr\",\"doi\":\"10.35787/jimdc.v12i1.896\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Testicular germ cell tumors are common solid organ malignancies in children with a survival rate of more than 90 %. This study aims to assess the predictors of relapse and survival in testicular germ cell tumors in children. \\nMethodology: A retrospective review was conducted on children up to the age of 18-years from January 2010 to December 2020 with a diagnosis of primary testicular germ cell tumors. Factors related to relapse and survival like age, baseline levels of tumor markers in serum and on relapse, stage at diagnosis, histological type, tumor laterality & size of the tumor in testicular germ cell tumors were analyzed. The data was entered into SPSS version 20. Statistical significance was set at a p-value ≤0.05. \\nResults: A total of 115 patients with a mean age of 5.42+ 1.54 years having testicular germ cell tumor were treated. Seventeen patients (14.7 %) had relapse of disease. Relapse was highest in patients with stage I disease (64.7 %). Yolk sac tumor was the most common pathology that was noted in twelve (70 %) patients. The most common site of relapse was the retroperitoneum (70 %). Age of patient, stage of disease, and lymphovascular invasion were significant predictors of relapse and survival in testicular germ cell tumors. \\nConclusion: Management of patients with testicular germ cell tumors requires standardized follow-up protocol for early detection and treatment of disease relapse. Complete surgical excision with meticulous control of the residual disease is critical to prevent disease relapse. \\nKeywords: Chemotherapy, Children, Outcome, Relapse, Testicular Tumor \\n \\n \",\"PeriodicalId\":33701,\"journal\":{\"name\":\"Journal of Islamabad Medical and Dental College\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Islamabad Medical and Dental College\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35787/jimdc.v12i1.896\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Islamabad Medical and Dental College","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35787/jimdc.v12i1.896","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:睾丸生殖细胞瘤是儿童常见的实体器官恶性肿瘤,生存率超过90%。本研究旨在评估儿童睾丸生殖细胞肿瘤复发和生存的预测因素。方法:对2010年1月至2020年12月诊断为原发性睾丸生殖细胞肿瘤的18岁以下儿童进行回顾性研究。分析与复发和生存相关的因素,如年龄、血清和复发时肿瘤标志物基线水平、诊断分期、组织学类型、肿瘤侧边及肿瘤大小。数据输入SPSS version 20。p值≤0.05,差异有统计学意义。结果:共治疗115例睾丸生殖细胞瘤患者,平均年龄5.42+ 1.54岁。17例(14.7%)复发。复发在I期患者中最高(64.7%)。卵黄囊肿瘤是最常见的病理,在12例(70%)患者中被注意到。最常见的复发部位是腹膜后(70%)。患者年龄、疾病分期和淋巴血管浸润是睾丸生殖细胞肿瘤复发和生存的重要预测因素。结论:睾丸生殖细胞肿瘤患者的治疗需要规范化的随访方案,以便及早发现和治疗疾病复发。完整的手术切除和细致的控制残留的疾病是防止疾病复发的关键。关键词:化疗,儿童,预后,复发,睾丸肿瘤
Predictors of Relapse and Survival in Testicular Germ cell Tumors in Children
Background: Testicular germ cell tumors are common solid organ malignancies in children with a survival rate of more than 90 %. This study aims to assess the predictors of relapse and survival in testicular germ cell tumors in children.
Methodology: A retrospective review was conducted on children up to the age of 18-years from January 2010 to December 2020 with a diagnosis of primary testicular germ cell tumors. Factors related to relapse and survival like age, baseline levels of tumor markers in serum and on relapse, stage at diagnosis, histological type, tumor laterality & size of the tumor in testicular germ cell tumors were analyzed. The data was entered into SPSS version 20. Statistical significance was set at a p-value ≤0.05.
Results: A total of 115 patients with a mean age of 5.42+ 1.54 years having testicular germ cell tumor were treated. Seventeen patients (14.7 %) had relapse of disease. Relapse was highest in patients with stage I disease (64.7 %). Yolk sac tumor was the most common pathology that was noted in twelve (70 %) patients. The most common site of relapse was the retroperitoneum (70 %). Age of patient, stage of disease, and lymphovascular invasion were significant predictors of relapse and survival in testicular germ cell tumors.
Conclusion: Management of patients with testicular germ cell tumors requires standardized follow-up protocol for early detection and treatment of disease relapse. Complete surgical excision with meticulous control of the residual disease is critical to prevent disease relapse.
Keywords: Chemotherapy, Children, Outcome, Relapse, Testicular Tumor