不同时期氟暴露大鼠氧化应激及碱性磷酸酶活性的研究

Q3 Medicine

中华地方病学杂志 Pub Date : 2010-03-20 DOI:10.3760/CMA.J.ISSN.1000-4955.2010.02.003

X. Hui, Fan Hai-qing, Zhang Jin-ming, Li Guang-sheng

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引用次数: 0

摘要

目的观察不同时期高氟暴露大鼠的氧化应激状态和碱性磷酸酶(ALP)活性，分析氟对氟中毒大鼠碱性磷酸酶(ALP)活性和氧化应激的影响。方法24只Wistar大鼠按体重分为对照组和高氟组，每组12只。对照组饮用自来水(氟化钠浓度0.05);高氟组血清尿酸水平在1、4周内显著高于对照组[(89.53±13.21)、(88.47±19.78)μmol/L][(77.79±11.43)、(65.42±3.42)μmol/L]，在8、12周内显著低于对照组[(67.21±9.44)、(73.95±9.52)μmol/L][(77.79±11.43)、(65.42±13.42)μmol/L]。结论氟过量对ALP的影响具有时间依赖性。另一方面，过量的氟化物会以一种与暴露时间无关的方式刺激氧化应激状态。关键词:氟化钠;氟中毒;氧化应激;碱性phosphatuse

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Study on oxidative stress and activity of alkaline phosphatase of rats exposed to different period of fluoride

Objective To observe the status of oxidative stress and activity of alkaline phosphatase(ALP) in rats exposed to high fluoride for the different periods and to analyze the effect of fluoride on the activity of ALP and oxidative stress in fluorosis rats. Methods Twenty-four Wistar rats were divided into control and high-fluoride groups according to their body mass, 12 rats in each group. The control group drank tap water(sodium fluoride concentrations 0.05); the level of uric acid in serum was significantly higher in high-fluoride group for 1,4 week[ (89.53 ± 13.21 ), (88.47 ± 19.78 )μmol/L] compared to the control [ (77.79 ± 11.43 ), (65.42 ± i 3.42) μ mol/L, all P < 0.05 ], but the level of uric acid showed lower in high-fluoride group for 8,12 week [(67.21 ± 9.44), (73.95 ± 9.52)μmol/L] compared to the control [(77.79 ± 11.43), (65.42 ± 13.42)μmol/L]. Conclusions Effect of overdose fluoride on ALP is time-dependant. On the other hand,overdose fluoride stimulates the status of oxidative stress in a way unrelated to the exposure period. Key words: Sodium fluoride; Fluoride poisoning; Oxidative stress; Alkaline phosphatuse

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来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.