Ronald B. Villanueva, Giuseppe Barbesino, David A. Greenberg, Erlinda Concepcion, Stefania Tucci, Terry F. Davies, Yaron Tomer
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The BTK Gene as Candidate Gene for Graves’ Disease
Graves’ disease (GD) results from an interplay of genetic factors and environmental triggers. We examined the immunoregulatory gene, Bruton’s tyrosine kinase (BTK), a candidate gene located in a region on chromosome Xq21.33−22 which we have previously found to be linked to GD and designated as GD-3. The study aimed to identify whether BTK was GD-3. No association was found between GD and alleles of the marker DXS178 and the A/C SNP. We concluded that BTK is not the GD-3 Graves’ disease susceptibility gene on chromosome Xq21.33−22.
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