海藻酸-果胶吸附剂对大鼠体内镉清除影响的研究

M. E. Shemaev, Alexandr Mikhajlovich Malov, R. K. Glushkov, K. Krasnov, Dmitrij Konstantinovich Shchegolihin, N. Lapina
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引用次数: 0

摘要

介绍。重金属对人体有严重的毒性作用。有足够的模型来消除毒物,并在此基础上测试肠道吸收剂,将提高中毒治疗的质量。材料和方法。为了评估吸附剂的有效性,使用了基于20天尿液和粪便中镉累积排泄数据的形式化模型。在实验的前三天,以每日3mg /kg的剂量给药醋酸镉,在研究期间,以100mg /kg的剂量口服肠吸收剂。采用反相伏安法测定了生物培养基中的镉含量。结果。在实验过程中,两组动物体内注射毒物的去除量均不超过3%。在本实验条件下,肠道吸收剂并未改变镉的排泄量,但影响了肾脏和肠道消除流之间的再分配。肠道吸收剂对肝脏中镉含量有显著影响。的局限性。在一段有限的时间内,对药物对消除毒物的影响进行了评估。用更长的观察期和其他金属及其剂量进行额外的实验,可以更详细地揭示所研究药物的有益特性。结论。肠道吸收剂对肝脏中镉含量有显著影响。镉可能会从肠道二次进入血液,这一过程对肾脏有负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research of the alginate-pectin sorbent influence on the elimination of cadmium from the body of rats
Introduction. Heavy metals have a serious toxic effect on the human body. The availability of adequate models for the elimination of toxicants and the testing of enterosorbents based on them will improve the quality of poisoning therapy. Material and methods. To assess the effectiveness of the sorbent, a formalized model based on data on the cumulative excretion of cadmium in urine and feces for 20 days was used. Intramuscular priming with cadmium acetate was carried out during the first three days of the experiment at a daily dose of 3 mg/ kg, the enterosorbent was administered orally at a dose of 100 mg/kg during the study. The cadmium content in the biological media was determined by methods of inversion voltammetry. Results. During the experiment, no more than 3% of the injected toxicant was removed from the animals of both groups. The enterosorbent in the conditions of the experiment did not change the amount of cadmium excreted, but affected the redistribution between the renal and intestinal elimination streams. A significant effect of the enterosorbent on the cadmium content in the liver was noted. Limitations. Evaluation of the effect of the drug on the elimination of the toxicant was carried out for a limited period of time. Additional experiments with longer observation periods and other metals and their dosages would allow to reveal in more detail the beneficial properties of the studied drug. Conclusion. A significant effect of the enterosorbent on the cadmium content in the liver was noted. There may be a secondary intake of cadmium into the blood from the intestine and a negative effect of this process on kidneys.
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