{"title":"一种选择性人工酚类雌激素化合物的分子印迹聚合物的合成及初步评价","authors":"J. Tarbin, M. Sharman","doi":"10.1039/A900197B","DOIUrl":null,"url":null,"abstract":"A molecularly imprinted polymer has been prepared using a hexestrol template. The polymer was synthesised using diethylaminoethyl methacrylate (DAEM) as functional monomer and trimethylolpropane trimethacrylate as cross-linking monomer via a photoinitiated addition polymerisation. An equivalent blank polymer was also synthesised in the absence of the template compound. After packing into a stainless steel column (150 × 4.6 mm id), retention and elution of the template and related compounds were evaluated by high-performance liquid chromatography (HPLC). The results showed that the material synthesised in the presence of hexestrol demonstrated a selectivity towards compounds containing the stilbene carbon backbone (diethylstilbestrol, dienestrol, hexestrol).","PeriodicalId":7814,"journal":{"name":"Analytical Communications","volume":"18 1","pages":"105-107"},"PeriodicalIF":0.0000,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":"{\"title\":\"Synthesis and preliminary evaluation of a molecularly imprinted polymer selective for artificial phenolic estrogenic compounds\",\"authors\":\"J. Tarbin, M. Sharman\",\"doi\":\"10.1039/A900197B\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A molecularly imprinted polymer has been prepared using a hexestrol template. The polymer was synthesised using diethylaminoethyl methacrylate (DAEM) as functional monomer and trimethylolpropane trimethacrylate as cross-linking monomer via a photoinitiated addition polymerisation. An equivalent blank polymer was also synthesised in the absence of the template compound. After packing into a stainless steel column (150 × 4.6 mm id), retention and elution of the template and related compounds were evaluated by high-performance liquid chromatography (HPLC). The results showed that the material synthesised in the presence of hexestrol demonstrated a selectivity towards compounds containing the stilbene carbon backbone (diethylstilbestrol, dienestrol, hexestrol).\",\"PeriodicalId\":7814,\"journal\":{\"name\":\"Analytical Communications\",\"volume\":\"18 1\",\"pages\":\"105-107\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/A900197B\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/A900197B","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
摘要
采用己甾醇模板制备了一种分子印迹聚合物。以甲基丙烯酸二乙胺乙酯(DAEM)为功能单体，三甲基丙烷三甲基丙烯酸三酯为交联单体，通过光引发加成聚合反应合成了该聚合物。在没有模板化合物的情况下，也合成了等效的空白聚合物。在不锈钢柱(150 × 4.6 mm id)中填充后，采用高效液相色谱法(HPLC)评价模板及相关化合物的保留和洗脱。结果表明，在己雌醇存在下合成的材料对含有二苯乙烯碳主链的化合物(二乙基己雌酚、二烯雌醇、己雌醇)具有选择性。
Synthesis and preliminary evaluation of a molecularly imprinted polymer selective for artificial phenolic estrogenic compounds
A molecularly imprinted polymer has been prepared using a hexestrol template. The polymer was synthesised using diethylaminoethyl methacrylate (DAEM) as functional monomer and trimethylolpropane trimethacrylate as cross-linking monomer via a photoinitiated addition polymerisation. An equivalent blank polymer was also synthesised in the absence of the template compound. After packing into a stainless steel column (150 × 4.6 mm id), retention and elution of the template and related compounds were evaluated by high-performance liquid chromatography (HPLC). The results showed that the material synthesised in the presence of hexestrol demonstrated a selectivity towards compounds containing the stilbene carbon backbone (diethylstilbestrol, dienestrol, hexestrol).
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