肠碱性磷酸酶对盲肠结扎和穿刺(CLP)诱导的脓毒症小鼠模型肠屏障功能的影响

Neurogastroenterology & Motility Pub Date : 2019-11-21 DOI:10.1111/nmo.13754

Philip Plaeke, J. D. De Man, A. Smet, S. Malhotra-Kumar, I. Pintelon, J. Timmermans, S. Nullens, P. Jorens, G. Hubens, B. D. De Winter

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引用次数: 12

摘要

脓毒症是一种与全身炎症、肠道炎症和胃肠道屏障功能障碍相关的严重病理状况。肠道碱性磷酸酶(IAP)已被证明可以解毒脂多糖，而脂多糖是脓毒症病理生理中的重要介质。我们研究了IAP治疗对肠通透性、肠道炎症和细菌易位的影响。

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Effects of intestinal alkaline phosphatase on intestinal barrier function in a cecal ligation and puncture (CLP)‐induced mouse model for sepsis

Sepsis is a severe pathological condition associated with systemic inflammation, intestinal inflammation, and gastrointestinal barrier dysfunction. Intestinal alkaline phosphatase (IAP) has been demonstrated to detoxify lipopolysaccharide, an important mediator in the pathophysiology of sepsis. We investigated the effect of treatment with IAP on intestinal permeability, intestinal inflammation, and bacterial translocation.

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Neurogastroenterology & Motility

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