P. Müller, Benjamin L. Bangasser, L. Greiner, Shukrallah Na’amnieh, P. Bäuerlein, D. Vogt, C. Müller
{"title":"双相对映选择性酶还原的稳定连续操作","authors":"P. Müller, Benjamin L. Bangasser, L. Greiner, Shukrallah Na’amnieh, P. Bäuerlein, D. Vogt, C. Müller","doi":"10.2174/1876214X01104010113","DOIUrl":null,"url":null,"abstract":"Continuous operation of alcohol dehydrogenase (ADH) catalysed enantioselective reduction in a biphasic sytem showed gains in productivity and stability of the overall reaction system. The total turnover numbers obtained for the cofactor NADP + are high with up to 1.5� 10 4 . Productivity for (R)-2-butanol with Lactobacillus brevis ADH was up to 26 kmol (mol enzyme) 1 . Enantioselectivity was greater than 0.99 for (R)-phenylethanol and up to 0.99 for (R)-butanol.","PeriodicalId":22755,"journal":{"name":"The Open Catalysis Journal","volume":"9 1","pages":"113-116"},"PeriodicalIF":0.0000,"publicationDate":"2011-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Stable Continuous Operation of a Biphasic Enantioselective Enzymatic Reduction\",\"authors\":\"P. Müller, Benjamin L. Bangasser, L. Greiner, Shukrallah Na’amnieh, P. Bäuerlein, D. Vogt, C. Müller\",\"doi\":\"10.2174/1876214X01104010113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Continuous operation of alcohol dehydrogenase (ADH) catalysed enantioselective reduction in a biphasic sytem showed gains in productivity and stability of the overall reaction system. The total turnover numbers obtained for the cofactor NADP + are high with up to 1.5� 10 4 . Productivity for (R)-2-butanol with Lactobacillus brevis ADH was up to 26 kmol (mol enzyme) 1 . Enantioselectivity was greater than 0.99 for (R)-phenylethanol and up to 0.99 for (R)-butanol.\",\"PeriodicalId\":22755,\"journal\":{\"name\":\"The Open Catalysis Journal\",\"volume\":\"9 1\",\"pages\":\"113-116\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Catalysis Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1876214X01104010113\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Catalysis Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876214X01104010113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stable Continuous Operation of a Biphasic Enantioselective Enzymatic Reduction
Continuous operation of alcohol dehydrogenase (ADH) catalysed enantioselective reduction in a biphasic sytem showed gains in productivity and stability of the overall reaction system. The total turnover numbers obtained for the cofactor NADP + are high with up to 1.5� 10 4 . Productivity for (R)-2-butanol with Lactobacillus brevis ADH was up to 26 kmol (mol enzyme) 1 . Enantioselectivity was greater than 0.99 for (R)-phenylethanol and up to 0.99 for (R)-butanol.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
