8年来麻疹、腮腺炎和风疹免疫疗法治疗皮肤疣的回顾性分析

IF 0.1 Q4 DERMATOLOGY
Ramandeep Kaur, S. Sood, I. Agrawal, B. Sharma
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引用次数: 0

摘要

简介:疣是由人乳头瘤病毒引起的良性病变。不同类型的皮肤疣包括寻常疣、生殖器疣和掌跖疣。不同的治疗方式可用于不同的反应疣。这些包括破坏性疗法、细胞毒性药物(博莱霉素)和免疫疗法(麻疹、腮腺炎和风疹[MMR]、念珠菌抗原等)。我们分析了瘤内MMR免疫治疗不同类型皮肤疣的疗效。目的:回顾性分析MMR免疫疗法治疗不同类型皮肤疣的有效性和安全性。材料与方法:纳入2014年3月至2022年3月期间接种MMR疫苗的所有皮肤疣患者。记录人口统计数据。每隔3周接种四剂MMR疫苗,或直至完全清除,以较早者为准。记录疣的清除和缩小以及潜在的副作用。结果:共入组184例患者,其中45%为女性。患者主要年龄为21 ~ 40岁。最常见的疣类型是掌跖疣。66%的患者完全缓解,22%的患者部分缓解。四肢的掌跖疣和疣对免疫治疗完全有效,而43%的生殖器疣没有改善。所有患者均出现注射部位疼痛,32%的患者出现流感样症状。结论:MMR疫苗免疫治疗在掌跖疣和四肢疣的治疗中显示出良好的反应,没有任何严重的不良反应,而生殖器疣和扁平疣对免疫治疗的反应不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retrospective analysis of treatment of cutaneous warts with measles, mumps, and rubella immunotherapy over 8 years
Introduction: Warts are benign lesions caused by human papilloma virus. Various types of cutaneous warts include verruca vulgaris, genital warts, and palmoplantar warts. Various therapeutic modalities are available for warts with varying response. These include destructive therapies, cytotoxic agents (Bleomycin), and immunotherapy (measles, mumps, and rubella [MMR], candida antigen, etc.). We have analyzed the efficacy of intralesional MMR immunotherapy in patients with different kinds of cutaneous warts. Aim: The purpose of this study was to retrospectively analyze the effectiveness and safety of MMR immunotherapy in the treatment of different kinds of cutaneous warts. Materials and Methods: We included all the patients with cutaneous warts receiving MMR vaccine between March 2014 and March 2022. Demographic data were recorded. MMR vaccine was given for four doses at 3 weeks interval or till there was complete clearance, whichever was earlier. Clearance and reduction of wart sizes and potential side effects were recorded. Results: A total of 184 patients were enrolled, and 45% patients were women. Predominant age group of patients was 21–40 years. Most common types of warts observed was palmoplantar warts. Complete resolution was seen in 66% patients and partial response in 22% patients. Palmo-plantar and warts on extremities responded completely to immunotherapy, whereas 43% of genital warts had no improvement. Pain at injection site was observed in all patients, and 32% patients had flu-like symptoms. Conclusions: Immunotherapy with MMR vaccine shows a promising response in the treatment of palmo-plantar warts and warts on extremities, without any serious adverse effect, whereas the genital warts and verruca plana respond variably to immunotherapy.
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