2019冠状病毒病后后遗症对男性生殖功能的影响:一项队列观察研究

IF 0.2 Q4 RESPIRATORY SYSTEM
M. Mousa, M. Elshazly, M. A. Abd El Salam, Salwa Ahmed
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引用次数: 0

摘要

冠状病毒SARS-COV-2已经影响了全世界数百万人,对身体系统和器官造成了很大的影响和损害,但其长期影响仍存在争议。到目前为止,人们正在进行大量研究,以评估2019冠状病毒病(COVID-19)对包括生殖在内的各个系统的有害影响,但仍存在争议。患者和方法本队列研究共纳入57例男性COVID-19患者,经鼻咽PCR拭子确诊为阳性。本研究的目的是评估COVID-19感染严重程度与出院后第1个月和第3个月精液参数和男性激素水平对男性生殖功能的影响。结果我们的研究结果显示,在感染后第1个月和第3个月,精子浓度、精子总数、进行性运动以及促卵泡激素、黄体生成素和e2激素水平的变化具有高度统计学意义,P值小于0.001。在相同背景下,睾酮激素水平差异有统计学意义,P值为0.003。根据COVID-19严重程度,严重程度与精子浓度、总活力和进行性活力的影响呈高度显著相关,P值小于0.001。相比之下,感染的严重程度与男性激素水平之间没有明显的相关性。结论COVID-19感染对精液参数以及男性性激素(促卵泡激素、黄体生成素、睾酮和E2)在感染后1个月和3个月均有负面影响;然而,只有精液参数受疾病严重程度的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Post-coronavirus disease 2019 sequelae on male-reproductive functions: A cohort observational study
Objectives The corona virus SARS-COV-2 has affected millions of people all over the world with much affection and damage to body systems and organs, and still, its long-term effects are debatable. Up till now, a lot of ongoing researches are being conducted to evaluate the deleterious effect of coronavirus disease 2019 (COVID-19) on various systems, including reproduction, however, it is still debatable. Patients and methods Our cohort study included a total of 57 male COVID-19 patients, confirmed positive via nasopharyngeal PCR swab. The aim of the study was to evaluate the correlation between the severity of COVID-19 infection and post-COVID sequelae on male-reproductive functions as regards semen parameters and male-hormone profile at the first and third month after discharge from the hospital. Results Our results have demonstrated highly statistically significant changes in sperm concentration, sperm total, and progressive motility, as well as follicle-stimulating hormone, luteinizing hormone, and E2-hormone levels on the first and third month post-COVID infection with P value less than 0.001. In the same context, there was a statistical significance to testosterone-hormone level with P value 0.003. According to COVID-19 severity, there was a highly significant correlation between the degree of severity and affection of sperm concentration, total, and progressive motility with P value less than 0.001. In contrast, there was no significant correlation between the severity of infection and male-hormone profile. Conclusion The current study revealed a negative influence of COVID-19 infection on semen parameters as well as male-sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and E2) on the first and third month post-COVID infection; however, only semen parameters were affected by the degree of disease severity.
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来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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