M. Mousa, M. Elshazly, M. A. Abd El Salam, Salwa Ahmed
{"title":"2019冠状病毒病后后遗症对男性生殖功能的影响:一项队列观察研究","authors":"M. Mousa, M. Elshazly, M. A. Abd El Salam, Salwa Ahmed","doi":"10.4103/ecdt.ecdt_15_22","DOIUrl":null,"url":null,"abstract":"Objectives The corona virus SARS-COV-2 has affected millions of people all over the world with much affection and damage to body systems and organs, and still, its long-term effects are debatable. Up till now, a lot of ongoing researches are being conducted to evaluate the deleterious effect of coronavirus disease 2019 (COVID-19) on various systems, including reproduction, however, it is still debatable. Patients and methods Our cohort study included a total of 57 male COVID-19 patients, confirmed positive via nasopharyngeal PCR swab. The aim of the study was to evaluate the correlation between the severity of COVID-19 infection and post-COVID sequelae on male-reproductive functions as regards semen parameters and male-hormone profile at the first and third month after discharge from the hospital. Results Our results have demonstrated highly statistically significant changes in sperm concentration, sperm total, and progressive motility, as well as follicle-stimulating hormone, luteinizing hormone, and E2-hormone levels on the first and third month post-COVID infection with P value less than 0.001. In the same context, there was a statistical significance to testosterone-hormone level with P value 0.003. According to COVID-19 severity, there was a highly significant correlation between the degree of severity and affection of sperm concentration, total, and progressive motility with P value less than 0.001. In contrast, there was no significant correlation between the severity of infection and male-hormone profile. Conclusion The current study revealed a negative influence of COVID-19 infection on semen parameters as well as male-sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and E2) on the first and third month post-COVID infection; however, only semen parameters were affected by the degree of disease severity.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Post-coronavirus disease 2019 sequelae on male-reproductive functions: A cohort observational study\",\"authors\":\"M. Mousa, M. Elshazly, M. A. Abd El Salam, Salwa Ahmed\",\"doi\":\"10.4103/ecdt.ecdt_15_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives The corona virus SARS-COV-2 has affected millions of people all over the world with much affection and damage to body systems and organs, and still, its long-term effects are debatable. Up till now, a lot of ongoing researches are being conducted to evaluate the deleterious effect of coronavirus disease 2019 (COVID-19) on various systems, including reproduction, however, it is still debatable. Patients and methods Our cohort study included a total of 57 male COVID-19 patients, confirmed positive via nasopharyngeal PCR swab. The aim of the study was to evaluate the correlation between the severity of COVID-19 infection and post-COVID sequelae on male-reproductive functions as regards semen parameters and male-hormone profile at the first and third month after discharge from the hospital. Results Our results have demonstrated highly statistically significant changes in sperm concentration, sperm total, and progressive motility, as well as follicle-stimulating hormone, luteinizing hormone, and E2-hormone levels on the first and third month post-COVID infection with P value less than 0.001. In the same context, there was a statistical significance to testosterone-hormone level with P value 0.003. According to COVID-19 severity, there was a highly significant correlation between the degree of severity and affection of sperm concentration, total, and progressive motility with P value less than 0.001. In contrast, there was no significant correlation between the severity of infection and male-hormone profile. Conclusion The current study revealed a negative influence of COVID-19 infection on semen parameters as well as male-sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and E2) on the first and third month post-COVID infection; however, only semen parameters were affected by the degree of disease severity.\",\"PeriodicalId\":46359,\"journal\":{\"name\":\"Egyptian Journal of Chest Diseases and Tuberculosis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Chest Diseases and Tuberculosis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ecdt.ecdt_15_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Chest Diseases and Tuberculosis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ecdt.ecdt_15_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Post-coronavirus disease 2019 sequelae on male-reproductive functions: A cohort observational study
Objectives The corona virus SARS-COV-2 has affected millions of people all over the world with much affection and damage to body systems and organs, and still, its long-term effects are debatable. Up till now, a lot of ongoing researches are being conducted to evaluate the deleterious effect of coronavirus disease 2019 (COVID-19) on various systems, including reproduction, however, it is still debatable. Patients and methods Our cohort study included a total of 57 male COVID-19 patients, confirmed positive via nasopharyngeal PCR swab. The aim of the study was to evaluate the correlation between the severity of COVID-19 infection and post-COVID sequelae on male-reproductive functions as regards semen parameters and male-hormone profile at the first and third month after discharge from the hospital. Results Our results have demonstrated highly statistically significant changes in sperm concentration, sperm total, and progressive motility, as well as follicle-stimulating hormone, luteinizing hormone, and E2-hormone levels on the first and third month post-COVID infection with P value less than 0.001. In the same context, there was a statistical significance to testosterone-hormone level with P value 0.003. According to COVID-19 severity, there was a highly significant correlation between the degree of severity and affection of sperm concentration, total, and progressive motility with P value less than 0.001. In contrast, there was no significant correlation between the severity of infection and male-hormone profile. Conclusion The current study revealed a negative influence of COVID-19 infection on semen parameters as well as male-sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and E2) on the first and third month post-COVID infection; however, only semen parameters were affected by the degree of disease severity.
期刊介绍:
The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.