能否进一步改善纳米级钛种植体表面以增强骨整合?

Souza Jcm, Sordi Mb, Kanazawa M, R. S, H. B., Silva Fs, Aparicio C, Cooper Lf
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引用次数: 0

摘要

本综述的主要目的是报告钛种植体表面技术改进的最新进展,以加速骨整合过程。几种表面改性方法按时间顺序进行了描述,将普通方法(如喷砂和蚀刻)和新型物理化学方法(如3d激光打印和仿生改性)连接起来。通过使用蛋白质、多肽和生物活性陶瓷的先进功能化程序,可以增强植入物表面的润湿性和生物活性。此外,最近的研究结果揭示了钛表面的微纳米级修饰和仿生功能化的综合有益效果。然而,由于成本和缺乏临床验证,植入物表面的一些技术发展尚未商业化。进一步的体外和体内研究是必要的,以支持使用增强的仿生植入物表面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can We Further Improve Titanium Implant Surfaces at Nanoscale to Enhance Osseointegration?
The main aim of this review study was to report the state of art on the technological improvements of titanium implant surfaces to accelerate the osseointegration process.Several methods of surface modification are chronologically described bridging ordinary methods (e.g. grit blasting and etching) and novel physicochemical approaches such as 3D-laser printing and biomimetic modification. Advanced functionalization procedures by using proteins, peptides, and bioactive ceramics have provided an enhancement of wettability and bioactivity of implant surfaces. Furthermore, recent findings have revealed a combined beneficial effect of micro- and nano-scale modification and biomimetic functionalization of titanium surfaces. However, some technological developments of implant surfaces are not commercially available yet due to costs and a lack of clinical validation of the novel surfaces. Further in vitro and in vivo studies are necessary to endorse of the use of enhanced biomimetic implant surfaces.
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