老年性和非老年性子宫内膜癌炎症标志物的比较。

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Biomarkers Pub Date : 2022-04-14 DOI:10.3233/cbm-210215

F. Vural, Ayşe Deniz Ertürk Coşkun, G. Çitak, B. Vural, G. Köse

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引用次数: 2

摘要

背景:炎症标志物与子宫内膜癌(EC)的不良临床结果相关，但造血老化可能会影响结果。目的比较老年性和非老年性EC的炎症标志物。方法本研究纳入342例子宫内膜癌患者(171例)和年龄匹配的对照组(171例)。对每组中年龄小于或等于65岁的老年妇女和非老年妇女进行炎症标志物、中性粒细胞/淋巴细胞比率(NLR)、血小板/淋巴细胞比率(PLR)、平均血小板体积(MPV)和血小板分布宽度(PDW)的比较。结果老年EC中非子宫内膜样肿瘤、子宫肌层侵袭、淋巴结转移、晚期、总生存率较低。与非老年对照组相比，非老年EC具有低MPV、高NLR和PDW。与对照组相比，老年EC患者MPV、淋巴细胞较低，NLR、PLR较高(p< 0.05)。与非老年EC相比，老年EC在早期阶段的PDW明显较低，NLR和PLR较高，而在晚期阶段则没有。淋巴细胞计数在老年EC各阶段均明显降低(p< 0.05)。在非老年性EC中，分期与血小板计数(r: 0.341, p: 0.0019)和PLR (r: 0.252, p: 0.01)相关。OS与PLR (r: -0.267, p: 0.007)、NLR (r: -0.353, p: 0.000)呈负相关。在老年EC中，肌层浸润与淋巴细胞计数呈负相关(r: -0.268, p: 0.035)。OS与中性粒细胞计数相关(p: 0.352, p: 0.01)。MPV与分期(r: -0.335, p: 0.01)和OS (r: -0.337, p: 0.02)呈负相关。结论老年性和非老年性EC在早期和晚期的炎症反应不同。与非老年EC相比，老年EC早期的PDW较低，NLR、PLR较高。淋巴细胞计数减少是老年EC早期和晚期最显著的特征。这些结果表明，淋巴细胞计数减少可能反映了老年人疾病的侵袭性过程。未来的炎症研究可能指导老年EC的抗癌治疗策略。需要对炎症和老年EC进行进一步的研究，以增加我们对衰老和致癌的理解。

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The comparison of inflammatory markers in geriatric and nongeriatric endometrial cancers.

BACKGROUND The inflammatory markers are associated with adverse clinical outcomes in endometrial cancers (EC), but hematopoietic aging may affect the results. OBJECTIVE To compare inflammatory markers in geriatric and nongeriatric EC. METHODS This study included 342 women with endometrial cancers (n: 171) and age-matched controls (n: 171). Geriatric (⩾ 65 years old) and nongeriatric women in each group was compared for inflammatory markers, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW). RESULTS Geriatric EC had more common nonendometrioid tumors, myometrial invasion, lymph node metastasis, advanced stage, and low overall survival (OS). Nongeriatric EC had low MPV, high NLR, and PDW compared to nongeriatric control. Geriatric EC had low MPV, lymphocyte, and high NLR, PLR compared to geriatric control (p< 0.05). Geriatric EC had significantly low PDW and high NLR, PLR compared to nongeriatric EC in early stages, not in advanced stages. Lymphocyte count was significantly low in geriatric EC with all stages (p< 0.05). In nongeriatric EC, stage was related to platelet count (r: 0.341, p: 0.0019), and PLR (r: 0.252, p: 0.01). OS was negatively related to PLR (r: -0.267, p: 0.007) and NLR (r: -0.353, p: 0.000). In geriatric EC, myometrium invasion was negatively related to lymphocyte count (r: -0.268, p: 0.035). OS was related to neutrophil count (p: 0.352, p: 0.01). MPV was negatively related to stage (r: -0.335, p: 0.01) and OS (r: -0.337, p: 0.02). CONCLUSIONS The inflammatory responses of geriatric and nongeriatric EC were different in the early and advanced stages. Geriatric EC had low PDW and high NLR, PLR compared to nongeriatric EC in early stages. Decreased lymphocyte count was the most prominent feature of geriatric EC in the early and advanced stages. These results suggested that decreased lymphocyte count may reflect an aggressive course of disease in the elderlies. Future inflammation studies may direct anticancer treatment strategies in geriatric EC. Further research on inflammaging and geriatric EC is needed to increase our understanding of aging and carcinogenesis.

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来源期刊

Cancer Biomarkers ONCOLOGY-

CiteScore

5.20

自引率

3.20%

发文量

195

审稿时长

3 months

期刊介绍： Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.