基底细胞癌角质层厚度与肿瘤细胞存活部分是否有关系?

IF 1.2 Q3 DERMATOLOGY

Journal of Skin Cancer Pub Date : 2016-01-28 DOI:10.1155/2016/6146091

O. Foss, P. Mjønes, S. Fismen, E. Christensen

{"title":"基底细胞癌角质层厚度与肿瘤细胞存活部分是否有关系?","authors":"O. Foss, P. Mjønes, S. Fismen, E. Christensen","doi":"10.1155/2016/6146091","DOIUrl":null,"url":null,"abstract":"Basal cell carcinoma (BCC) is an invasive epithelial skin tumour. The thickness of the outermost epidermal layer of the skin, the stratum corneum (SC), influences drug uptake and penetration into tumour and may thereby affect the response of BCC to topical treatment. The aim was to investigate a possible relationship between the thickness of the SC and that of the viable part of BCC. Histopathological evaluations of the corresponding SC and viable tumour thickness measurements of individual BCCs of different subtypes were explored. A total of 53 BCCs from 46 patients were studied. The median tumour thickness was 1.7 mm (0.8–3.0 mm), with a significant difference between subtypes (p < 0.001). The SC had a median thickness of 0.3 mm (0.2–0.4 mm), with no difference between tumour subtypes (p = 0.415). Additionally, no significant association between the thickness of the SC and that of the viable part of the tumour was demonstrated (p = 0.381). In conclusion our results indicate that SC thickness is relatively constant in BCC.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"35 1","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2016-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Is There a Relationship between the Stratum Corneum Thickness and That of the Viable Parts of Tumour Cells in Basal Cell Carcinoma?\",\"authors\":\"O. Foss, P. Mjønes, S. Fismen, E. Christensen\",\"doi\":\"10.1155/2016/6146091\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Basal cell carcinoma (BCC) is an invasive epithelial skin tumour. The thickness of the outermost epidermal layer of the skin, the stratum corneum (SC), influences drug uptake and penetration into tumour and may thereby affect the response of BCC to topical treatment. The aim was to investigate a possible relationship between the thickness of the SC and that of the viable part of BCC. Histopathological evaluations of the corresponding SC and viable tumour thickness measurements of individual BCCs of different subtypes were explored. A total of 53 BCCs from 46 patients were studied. The median tumour thickness was 1.7 mm (0.8–3.0 mm), with a significant difference between subtypes (p < 0.001). The SC had a median thickness of 0.3 mm (0.2–0.4 mm), with no difference between tumour subtypes (p = 0.415). Additionally, no significant association between the thickness of the SC and that of the viable part of the tumour was demonstrated (p = 0.381). In conclusion our results indicate that SC thickness is relatively constant in BCC.\",\"PeriodicalId\":17172,\"journal\":{\"name\":\"Journal of Skin Cancer\",\"volume\":\"35 1\",\"pages\":\"\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2016-01-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Skin Cancer\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2016/6146091\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Skin Cancer","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2016/6146091","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 3

摘要

基底细胞癌(BCC)是一种侵袭性皮肤上皮肿瘤。皮肤最外表皮层角质层(SC)的厚度影响药物的吸收和对肿瘤的渗透，从而可能影响BCC对局部治疗的反应。目的是研究SC的厚度与BCC的可存活部分的厚度之间可能的关系。探讨了不同亚型的单个bcc相应SC的组织病理学评估和活肿瘤厚度测量。来自46例患者的53例bcc被研究。肿瘤中位厚度为1.7 mm (0.8 ~ 3.0 mm)，不同亚型间差异有统计学意义(p < 0.001)。SC的中位厚度为0.3 mm (0.2-0.4 mm)，不同肿瘤亚型间无差异(p = 0.415)。此外，SC的厚度与肿瘤存活部分的厚度之间无显著相关性(p = 0.381)。总之，我们的结果表明，在BCC中SC的厚度是相对恒定的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Is There a Relationship between the Stratum Corneum Thickness and That of the Viable Parts of Tumour Cells in Basal Cell Carcinoma?

Basal cell carcinoma (BCC) is an invasive epithelial skin tumour. The thickness of the outermost epidermal layer of the skin, the stratum corneum (SC), influences drug uptake and penetration into tumour and may thereby affect the response of BCC to topical treatment. The aim was to investigate a possible relationship between the thickness of the SC and that of the viable part of BCC. Histopathological evaluations of the corresponding SC and viable tumour thickness measurements of individual BCCs of different subtypes were explored. A total of 53 BCCs from 46 patients were studied. The median tumour thickness was 1.7 mm (0.8–3.0 mm), with a significant difference between subtypes (p < 0.001). The SC had a median thickness of 0.3 mm (0.2–0.4 mm), with no difference between tumour subtypes (p = 0.415). Additionally, no significant association between the thickness of the SC and that of the viable part of the tumour was demonstrated (p = 0.381). In conclusion our results indicate that SC thickness is relatively constant in BCC.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Skin Cancer DERMATOLOGY-

CiteScore

2.30

自引率

18.20%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Skin Cancer is a peer-reviewed, Open Access journal that publishes clinical and translational research on the detection, diagnosis, prevention, and treatment of skin malignancies. The journal encourages the submission of original research articles, review articles, and clinical studies related to pathology, prognostic indicators and biomarkers, novel therapies, as well as drug sensitivity and resistance.