人类乳头状瘤病毒在口腔鳞状细胞癌中的作用——谜团解开。

Komal Khot, Swati P. Deshmane, Sheetal S Choudhari
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引用次数: 13

摘要

长期以来,头颈部鳞状细胞癌(HNSCC)一直被认为是世界范围内发病率高、预后较差的疾病。因此,鼓励进一步研究可能改变疾病结果的因素。鳞状细胞癌至少占所有口腔恶性肿瘤的90%。一些因素,如烟草和烟草相关产品、酒精、遗传易感性和激素因素被怀疑是可能的致病因素。人乳头瘤病毒(HPV),宫颈癌的致病因子似乎也参与口腔癌和口咽癌的病因学。hpv阳性鳞状细胞癌(SCC)似乎不同于hpv阴性鳞状细胞癌。关于口腔HPV感染的自然史的许多问题仍在调查中。本综述的目的是强调目前对hpv相关口腔癌的认识,重点是其预后,检测和管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human Papilloma Virus in Oral Squamous Cell Carcinoma - The Enigma Unravelled.
Squamous cell carcinoma of the head and neck (HNSCC) has long been regarded as a disease entity having a remarkable incidence worldwide and a fairly onerous prognosis; thus encouraging further research on factors that might modify disease outcome. Squamous cell carcinomas encompass at least 90% of all oral malignancies. Several factors like tobacco and tobacco-related products, alcohol, genetic predisposition and hormonal factors are suspected as possible causative factors. Human papilloma virus (HPV), the causal agent of cervical cancer also appears to be involved in the aetiology of oral and oropharyngeal cancer. HPVpositive squamous cell carcinoma (SCC) seems to differ from HPV-negative SCC. Many questions about the natural history of oral HPV infection remain under investigation. The aim of this review is to highlight the current understanding of HPV-associated oral cancer with an emphasis on its prognosis, detection and management.
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