鱼类补体C3基因的研究进展

IF 0.5 4区 农林科学 Q4 FISHERIES
Rumeng Jin, H. Xia, Pinhong Yang, Juanjuan Lu, Fuyan Chen, Yunsheng Zhang, Liangguo Liu, Zhongyuan Chen, Hao Zeng, Wei Zhou, Huimin Liu, Shanhong Liu
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引用次数: 0

摘要

补体(C)是一种具有免疫相关功能和酶活性的血清蛋白。它可以诱导炎症反应,并在病原体等物质激活后形成抗体。此外,它是先天性免疫防御系统的关键分子。在鱼类免疫系统的进化过程中,补体比免疫球蛋白更早出现。因此,鱼类的补体系统对先天免疫和获得性免疫至关重要。补体系统是由30多种可溶性蛋白、膜结合蛋白和补体受体组成的多分子系统。它可以通过免疫调节、清除免疫复合物等三种途径被激活。肝脏主要产生鱼类补体C3,这是鱼类补体系统的重要组成部分。C3是三条激活通路的中枢。本文综述了鱼类中C3的结构、产生过程、表达和功能等方面的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress on the Fish Complement C3 Gene
Complement (C) is a serum protein with immunity-related functions and enzymatic activities. It can induce inflammatory responses and antibody formation following activation by substances such as pathogens. Moreover, it is a crucial molecule in the congenital immune defense system. Complement manifests earlier than immunoglobulin in the evolutionary process of fish’s immune system. Therefore, the complement system of fish is vital for congenital and acquired immunities. A complement system is a polymolecule system comprising more than 30 soluble proteins, membrane-bound proteins, and complement receptors. It can be activated through three pathways for immunoregulation, the clearance of the immune complex, etc. The liver primarily produces the fish complement C3, which is a significant component of the complement system of fishes. C3 is the hub of three activation pathways. Research works concerning the structure, generation process, expression, and functions of C3 in fishes are reviewed in this study.
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来源期刊
CiteScore
0.90
自引率
16.70%
发文量
49
审稿时长
3 months
期刊介绍: Information not localized
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