39周引产应常规提供给低风险妇女

B. D. de Vries, A. Gordon
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引用次数: 6

摘要

2007年,新的Cochrane系统综述发表了一张海报,显示在低风险妊娠中,孕周前40周的引产(IOL)可以防止剖腹产。风险比为0.68 (95% CI 0.34-0.99)我惊呆了。作者建议在低风险妇女中进行一项澳大利亚随机对照试验,以改善围产期结局。它没有进行,但美国抵达试验于2018年发表。6106例低风险无生育单胎妊娠妇女在39+ 0-39 +4周随机接受计划人工晶状体治疗或期待治疗重度围产期并发症发生率分别为IOL组的4.3%和准组的5.4% (P = 0.049)。人工晶状体组的剖宫产率为18.6%,孕妇组为22.2% (P < 0.001)。几乎立即,美国妇产科学院表示,“产科医生和医疗机构为妊娠39周的低风险无产妇女提供选择性引产是合理的”,这一观点得到了母胎医学协会的认可。3然而,该试验也因缺乏通适性、与观察数据存在差异而招致批评。是否有其他方法降低剖宫产率及成本效益未知。女性是否应该在39周时选择人工晶状体,从而承认女性的自主权?还是说39周的人工晶状体有明显的错误,不应该作为一种选择来讨论,甚至在被要求时主动拒绝?这篇观点文章的目的是讨论为低风险妇女提供39周孕龄人工晶状体的情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Induction of labour at 39 weeks should be routinely offered to low‐risk women
Then, in 2007, a poster was presented from the new Cochrane systematic review, which showed that in lowrisk pregnancies, induction of labour (IOL) before 40 weeks’ gestational age prevented caesarean section. The risk ratio was 0.68 (95% CI 0.34–0.99).1 I was astounded. The authors proposed an Australian randomised controlled trial among lowrisk women for improving perinatal outcomes. It was not undertaken, but the USA ARRIVE Trial was published in 2018. A total of 6106 lowrisk nulliparous women with singleton pregnancies were randomised to planned IOL at 39+0–39+4 weeks or expectant management.2 Severe perinatal complications occurred in 4.3% infants in the IOL group and 5.4% in the expectant group (P = 0.049). Caesarean section occurred in 18.6% of women in the IOL group and 22.2% in the expectant group (P < 0.001). Almost immediately, the American College of Obstetricians and Gynaecologists stated ‘it is reasonable for obstetricians and healthcare facilities to offer elective induction of labor to lowrisk nulliparous women at 39 weeks’ gestation’, a view endorsed by the Society for MaternalFetal Medicine.3 However, the trial also drew criticism based on the perceived lack of generalisability, discrepancies with observational data, availability of other methods to reduce caesarean section rates and unknown costeffectiveness.4–6 Should women be able to choose IOL at 39 weeks, thereby acknowledging a woman's right to autonomy? Or is IOL at 39 weeks so obviously wrong that it should not be discussed as an option, or even actively refused if requested? The aim of this opinion article is to argue the case for offering IOL 39 weeks’ gestational age to lowrisk women.
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