{"title":"渗透剂与角质层脂质氢键与扩散的关系","authors":"W. Pugh","doi":"10.1081/CUS-120001862","DOIUrl":null,"url":null,"abstract":"It is generally accepted that the barrier to permeation is effectively the outermost 10–15mm of the skin (1–3). To overcome this stratum corneum (SC) obstacle, a molecule must first enter and then cross it. Fick’s law relates the steady-state flux, Js, to the concentration gradient across the SC. If the viable dermis is regarded as a sink, the gradient determining the flux is Csc/h. Since the partition coefficient K of a solute between the SC and vehicle can be written as Csc /Cv, Js can be expressed as: Js 1⁄4 ADKCv=h","PeriodicalId":17547,"journal":{"name":"Journal of Toxicology-cutaneous and Ocular Toxicology","volume":"7 1","pages":"303 - 317"},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Relationship between H-bonding of penetrants to stratum corneum lipids and diffusion\",\"authors\":\"W. Pugh\",\"doi\":\"10.1081/CUS-120001862\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"It is generally accepted that the barrier to permeation is effectively the outermost 10–15mm of the skin (1–3). To overcome this stratum corneum (SC) obstacle, a molecule must first enter and then cross it. Fick’s law relates the steady-state flux, Js, to the concentration gradient across the SC. If the viable dermis is regarded as a sink, the gradient determining the flux is Csc/h. Since the partition coefficient K of a solute between the SC and vehicle can be written as Csc /Cv, Js can be expressed as: Js 1⁄4 ADKCv=h\",\"PeriodicalId\":17547,\"journal\":{\"name\":\"Journal of Toxicology-cutaneous and Ocular Toxicology\",\"volume\":\"7 1\",\"pages\":\"303 - 317\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Toxicology-cutaneous and Ocular Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1081/CUS-120001862\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicology-cutaneous and Ocular Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1081/CUS-120001862","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Relationship between H-bonding of penetrants to stratum corneum lipids and diffusion
It is generally accepted that the barrier to permeation is effectively the outermost 10–15mm of the skin (1–3). To overcome this stratum corneum (SC) obstacle, a molecule must first enter and then cross it. Fick’s law relates the steady-state flux, Js, to the concentration gradient across the SC. If the viable dermis is regarded as a sink, the gradient determining the flux is Csc/h. Since the partition coefficient K of a solute between the SC and vehicle can be written as Csc /Cv, Js can be expressed as: Js 1⁄4 ADKCv=h
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