立体定向放射治疗在晚期肾细胞癌中的应用

国际肿瘤学杂志 Pub Date : 2019-10-08 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.10.013

Liang Cai, Yali Shen

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引用次数: 0

摘要

立体定向放射治疗(SBRT)可通过缺氧诱导因子-1α和酸性鞘磷脂酶等生物分子有效杀伤肾癌细胞。较高生物剂量、单次照射的SBRT方案能更有效地局部控制晚期肾癌的原发和转移灶，且不良反应可耐受。SBRT联合靶向药物可增加肾癌对放疗的敏感性，SBRT联合免疫药物可通过体外作用增强免疫应答。SBRT治疗晚期肾癌的疗效有待探讨。关键词:肾肿瘤;先进的肿瘤;立体定向全身放射治疗

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Application of stereotactic body radiation therapy in advanced renal cell carcinoma

Stereotactic body radiation therapy (SBRT) can effectively kill renal cancer cells by biological molecules such as hypoxia-inducible factor-1α and acid sphingomyelinase. SBRT regimen with higher biological dose and single irradiation can achieve more effective local control of primary and metastatic lesion of advanced renal cancer, and adverse reactions can be tolerated. Combination of SBRT and targeted drugs can increase the sensitivity of renal cancer to radiotherapy, and the combination of SBRT and immune drugs can enhance the immune response through the abscopal effect. The efficacy of SBRT in the treatment of advanced renal cancer remains to be explored. Key words: Kidney neoplasms; Advanced tumor; Stereotactic body radiation therapy

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国际肿瘤学杂志

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12123

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