Using Inj. Ondansetron in pregnant female during LSCS? Beware!

Prevention of postdelivery intraoperative nausea and vomiting (IONV) is one of the concerns of anesthesiologist during surgery. The main aim is to keep the patient as comfortable as possible perioperatively. Various drugs, especially prokinetics and serotonin receptor antagonists, are frequently used to overcome IONV. Among them, ondansetron is most commonly used due to lack of drug interactions and good potency. Although rare, various side effects including cardiovascular system are found with this drug. We encountered a case of symptomatic sinus bradycardia with ventricular ectopic beats after rapid intravenous ondansetron in a 31-year-old pregnant lady posted for emergency lower segment cesarean section.