环境压力影响下流行病模型的动力学

Q3 Mathematics
Sangeeta Saha, G. Samanta
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引用次数: 0

摘要

为了观察环境胁迫对疾病传播的影响,我们考虑了传染病的区隔流行病学模型。所提出的模型定义良好,因为每个隔间的人口保持正值并随时间有界。通过稳定性分析和平衡点的分岔分析,观察了模型的动力学行为。数值模拟也支持了理论证明,结果表明系统在无病平衡点附近发生了前向分岔。结果表明,随着环境污染的加重,感染总人数增加。此外,易感人群和应激人群中无症状感染者的疾病传播率对系统流行起着至关重要的作用。并提出了相应的最优控制问题,通过选择感染前的疫苗接种政策和对感染者的治疗政策作为控制变量,在控制疾病流行的同时使成本最小化。数值表明,向易感人群提供疫苗接种需要一段时间才能减少疾病传播,而向应激人群提供疫苗接种在实施后立即起作用。对有症状感染者的治疗政策在早期阶段的效果较高,但强度随着时间的推移而降低。同时实施所有控制干预措施对于减少总体感染个体的规模和最大限度地减少经济负担更为有用。因此,本研究清楚地表达了环境污染(特别是环境应激的影响)对疾病在人群中的传播的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamics of an Epidemic Model under the Influence of Environmental Stress
We have considered a compartmental epidemiological model with infectious disease to observe the influence of environmental stress on disease transmission. The proposed model is well-defined as the population at each compartment remains positive and bounded with time. Dynamical behaviour of the model is observed by the stability and bifurcation analysis at the equilibrium points. Also, numerical simulation supports the theoretical proofs and the result shows that the system undergoes a forward bifurcation around the disease-free equilibrium. Our results indicate that with the increase of environmental pollution, the overall infected population increases. Also, the disease transmission rate among the susceptible and stressed population from asymptomatically infected individuals plays a crucial role to make a system endemic. A corresponding optimal control problem has also been proposed to control the disease prevalence as well as to minimize the cost by choosing the vaccination policy before being infected and treatment policy to the infected as control variables. Numerical figures indicate that the vaccination provided to susceptible needs some time to reduce the disease transmission but the vaccination provided to stressed individuals works immediately after implementation. The treatment policy for symptomatically infected individuals works with a higher rate at an earlier stage but the intensity decreases with time. Simultaneous implementation of all control interventions is more useful to reduce the size of overall infective individuals and also to minimize the economic burden. Hence, this research clearly expresses the impact of environmental pollution (specifically the influence of environmental stress) on the disease transmission in the population.
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来源期刊
Mathematical Biology and Bioinformatics
Mathematical Biology and Bioinformatics Mathematics-Applied Mathematics
CiteScore
1.10
自引率
0.00%
发文量
13
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