浓缩纤维蛋白原在外科病人中的疗效和安全性:一项随机对照试验的荟萃分析

E. Fominskiy, V. A. Nepomniashchikh, V. Lomivorotov, F. Monaco, Chiara Vitiello, A. Zangrillo, G. Landoni
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引用次数: 0

摘要

B型血是手术中和手术后常见且突出的并发症。失血过多与重症监护和机械通气时间延长、发病率和死亡率增加以及总体卫生保健费用增加有关。输血用于治疗出血和凝血功能障碍,但异体红细胞(rbc)和新鲜冷冻血浆的使用可能导致手术后不良后果。使用纤维蛋白原浓缩物(FC)治疗凝血障碍出血可以减少异体血液制品输血的使用,因为纤维蛋白原有助于止血的实现和维持。一项随机对照研究(RCTs)的荟萃分析比较了纤维蛋白原补充与安慰剂或其他止血治疗(新鲜冷冻血浆、血小板、冷冻沉淀和凝血因子浓缩物)在围手术期的效果
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and Safety of Fibrinogen Concentrate in Surgical Patients: A Meta-analysis of Randomized Controlled Trials
B leeding is a common and prominent complication during and after surgery. Excessive blood loss is associated with prolonged length of intensive care and mechanical ventilation, increased morbidity and mortality, and higher overall health care costs. Blood product transfusions are used for the management of bleeding and coagulopathy, but the use of allogeneic red blood cells (RBCs) and fresh frozen plasma can lead to adverse outcomes after surgery. Treating coagulopathic bleeding using fibrinogen concentrate (FC) could reduce the use of allogeneic blood product transfusion as fibrinogen contributes to the achievement and maintenance of hemostasis. A meta-analysis of randomized controlled studies (RCTs) comparing fibrinogen supplementation with placebo or other hemostatic treatments (fresh frozen plasma, platelets, cryoprecipitate, and coagulation factor concentrates) in the perioperative setting was carried out to investigate the effects
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