心室心肌细胞局部Ca2+释放单元的高效和详细模型。

T. Schendel, M. Falcke
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引用次数: 4

摘要

我们在这里提出了一种有效但详细的方法来模拟Ca(2+)诱导的Ca(2+)释放在心室肌细胞双裂中。在这个框架中,我们开发了一个空间分辨率的Ca(2+)释放单元(CaRU),由连接肌浆网和斜裂组成,具有明确的通道放置。利用时间尺度的分离,模型最终可以简化为一个描述Ca(2+)通量和扩散的常微分方程。此外,通道门控以随机方式描述。所得到的模型能够再现实验结果,如SR释放的梯度,ECC增益的电压依赖性和典型的火花寿命。由于该模型的数值效率高,适合用于整个细胞的模拟。我们想要使用的方法是将开发的(CaRU)扩展到这样一个完整的细胞模型,在这项工作中已经概述了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficient and detailed model of the local Ca2+ release unit in the ventricular cardiac myocyte.
We present here an efficient but detailed approach to modelling Ca(2+)-induced Ca(2+) release in the diadic cleft of cardiac ventricular myocytes. In this Framework we developed a spatial resolved Ca(2+) release unit (CaRU), consisting of the junctional sarcoplasmic reticulum and the diadic cleft, with a well defined channel placement. By taking advantage of time scale separation, the model could be finally reduced to only one ordinary differential equation for describing Ca(2+) fluxes and diffusion. Additionally the channel gating is described in a stochastic way. The resulting model is able to reproduce experimental findings like the gradedness of SR release, the voltage dependence of ECC gain and typical spark life time. Due to the numerical efficiency of the model, it is suitable to use for whole cell simulations. The approach we want to use extend the developed (CaRU) to such a whole cell model is already outlined in this work.
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