Solvent-free Organic Reaction Techniques as an Approach for Green Chemistry

Unfortunately, many toxic solvents are used in chemistry laboratories and in the manufacturing of materials, which poses a serious risk to process safety, the natural environment, and human health. In this review, different tools for solvent-free organic reactions have been surveyed as an approach for green chemistry, where many of the solvents are known to upset our ecosystems so an enormous research effort has been exerted during the last decade to avoid the utilization of hazardous solvents and the number of publications on solvent-free reactions has increased nearly exponentially. Obviously, this reflects the great interest in solventless reactions. In our survey, we will highlight the solvent-free organic reaction as an approach for green chemistry to cover work published up to nearly 2022.