目前埃博拉病毒的治疗方法

生命科学研究 Pub Date : 2014-11-14 DOI:10.2875/.v1i1.1

Lokesh Sharma

{"title":"目前埃博拉病毒的治疗方法","authors":"Lokesh Sharma","doi":"10.2875/.v1i1.1","DOIUrl":null,"url":null,"abstract":"Ebola virus disease (EVD) developed in a patient who contracted the disease in Sierra Leone and was airlifted to an isolation facility in Hamburg, Germany, for treatment. During the course of the illness, he had numerous complications, including septicemia, respiratory failure, and encephalopathy. Intensive supportive treatment consisting of high-volume fluid resuscitation (approximately 10 liters per day in the first 72 hours), broad-spectrum antibiotic therapy, and ventilatory support resulted in full recovery without the use of experimental therapies. Discharge was delayed owing to the detection of viral RNA in urine (day 30) and sweat (at the last assessment on day 40) by means of polymerase-chain-reaction (PCR) assay, but the last positive culture was identified in plasma on day 14 and in urine on day 26. This case shows the challenges in the management of EVD and suggests that even severe EVD can be treated effectively with routine intensive care.","PeriodicalId":18198,"journal":{"name":"生命科学研究","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2014-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Current Approaches of Ebola Virus’s\",\"authors\":\"Lokesh Sharma\",\"doi\":\"10.2875/.v1i1.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ebola virus disease (EVD) developed in a patient who contracted the disease in Sierra Leone and was airlifted to an isolation facility in Hamburg, Germany, for treatment. During the course of the illness, he had numerous complications, including septicemia, respiratory failure, and encephalopathy. Intensive supportive treatment consisting of high-volume fluid resuscitation (approximately 10 liters per day in the first 72 hours), broad-spectrum antibiotic therapy, and ventilatory support resulted in full recovery without the use of experimental therapies. Discharge was delayed owing to the detection of viral RNA in urine (day 30) and sweat (at the last assessment on day 40) by means of polymerase-chain-reaction (PCR) assay, but the last positive culture was identified in plasma on day 14 and in urine on day 26. This case shows the challenges in the management of EVD and suggests that even severe EVD can be treated effectively with routine intensive care.\",\"PeriodicalId\":18198,\"journal\":{\"name\":\"生命科学研究\",\"volume\":\"3 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"生命科学研究\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2875/.v1i1.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"生命科学研究","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2875/.v1i1.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

埃博拉病毒病(EVD)发生在一名在塞拉利昂感染该疾病的患者身上，该患者被空运到德国汉堡的一个隔离设施接受治疗。在患病过程中，他出现了许多并发症，包括败血症、呼吸衰竭和脑病。包括大容量液体复苏(最初72小时内每天约10升)、广谱抗生素治疗和呼吸支持在内的强化支持治疗使患者在没有使用实验性治疗的情况下完全康复。通过聚合酶链反应(PCR)检测尿液(第30天)和汗液(第40天最后一次评估)中检测到病毒RNA，延迟了出院时间，但在第14天的血浆和第26天的尿液中检测到最后一次阳性培养。这一病例显示了埃博拉病毒病管理方面的挑战，并表明即使是严重的埃博拉病毒病也可以通过常规重症监护得到有效治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Current Approaches of Ebola Virus’s

Ebola virus disease (EVD) developed in a patient who contracted the disease in Sierra Leone and was airlifted to an isolation facility in Hamburg, Germany, for treatment. During the course of the illness, he had numerous complications, including septicemia, respiratory failure, and encephalopathy. Intensive supportive treatment consisting of high-volume fluid resuscitation (approximately 10 liters per day in the first 72 hours), broad-spectrum antibiotic therapy, and ventilatory support resulted in full recovery without the use of experimental therapies. Discharge was delayed owing to the detection of viral RNA in urine (day 30) and sweat (at the last assessment on day 40) by means of polymerase-chain-reaction (PCR) assay, but the last positive culture was identified in plasma on day 14 and in urine on day 26. This case shows the challenges in the management of EVD and suggests that even severe EVD can be treated effectively with routine intensive care.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

生命科学研究

自引率

0.00%

发文量

2529

期刊介绍： "Life Science Research" is a comprehensive academic journal approved by the Press and Publication Administration of the People's Republic of China and the Ministry of Science and Technology. It is publicly distributed at home and abroad and reflects the latest research results in the field of life sciences. It is sponsored by the School of Life Sciences of Hunan Normal University. This journal mainly publishes creative academic papers in the field of life sciences at home and abroad, as well as a small number of news or review articles reflecting major progress or hot issues at home and abroad. The columns are mainly: Expert Forum, Exosome Column, Non-coding RNA Column, New Coronavirus Column, Ecology Column, Biochemistry and Molecular Biology, Genetics and Development, Tumor Mechanism, Cell and Physiology, Biological Classification, Bioinformatics, Basic Medicine, Technology and Application, University Teaching Reform Research and Practice, etc.