线粒体-内质网相互作用:终生的开关关系?

Corina T Madreiter-Sokolowski, Roland M Malli, Wolfgang F Graier
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引用次数: 0

摘要

这篇文章评论了最近的一些出版物,这些出版物强调了线粒体和内质网之间相互作用中特定设置的有趣重要性,以确保细胞特异性功能,如胰腺β细胞对葡萄糖升高的反应性。因此,在衰老或癌症等各种病理条件下,线粒体-内质网通讯的改变往往伴随着Ca2+转移的增强,这反过来又会刺激基础线粒体活性,以满足细胞对三磷酸腺苷不断增加的需求。这些观察结果确定了线粒体相关膜作为对抗衰老或癌症的新治疗策略的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mitochondrial-Endoplasmic Reticulum Interplay: A Lifelong On-Off Relationship?

Mitochondrial-Endoplasmic Reticulum Interplay: A Lifelong On-Off Relationship?

This article comments recent publications that highlight an intriguing importance of specific settings in the interaction between the mitochondria and the endoplasmic reticulum to ensure cell-specific functions like the responsiveness to elevated glucose in pancreatic β-cells. Hence, alterations of the mitochondria-endoplasmic reticulum communications under various pathological conditions like aging or cancer often come with enhanced Ca2+ transfer that, in turn, yields stimulation of basal mitochondrial activity to meet the increasing adenosine triphosphate demand of the very cell. Such observations identify mitochondria-associated membranes as potential target for new therapeutic strategies against aging or cancer.

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