社会健康因素对晚期2型子宫内膜癌诊断的影响[j]

P. Blustein, K. Dillon, E. Pereira, J. Villella, S. Werner
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引用次数: 0

摘要

2型子宫内膜癌(T2EC)占所有子宫内膜癌的38.7%,但占子宫内膜癌死亡人数的74.6%。这可能是由于诊断时处于晚期。我们研究健康的社会决定因素是否与晚期诊断的T2EC相关。方法:回顾性分析2015年5月1日至2022年3月31日在一个学术站点的T2EC病例。主要终点为手术诊断时的晚期,定义为FIGO 3期或4期。评估患者的年龄、种族、种族(白人与非白人)、肥胖和糖尿病。采用多因素logistic回归模型探讨与晚期疾病(ASD)风险增加相关的预测因素,双侧P值<。0.05认为显著。结果:共发现72例T2EC患者。38例(52.7%)诊断为早期疾病,34例(47.3%)诊断为ASD。种族是唯一与主要结果显著相关的预测因子。与非西班牙裔或拉丁裔相比,西班牙裔或拉丁裔在诊断时与ASD的比值(比值比5.1,95% CI 1.2-21.6, P= 0.028)高出5倍。结论:我们的研究结果显示,西班牙裔或拉丁裔与晚期诊断有显著相关性。非白人种族、肥胖、糖尿病和手术年龄未被发现是与主要结果显著相关的预测因素。这可能是由于样本量的限制。为了促进健康公平,继续需要调查健康的社会决定因素对2型ec的ASD的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Social Determinants of Health on Advanced Stage Type 2 Endometrial Cancer at Time of Diagnosis [ID: 1376689]
INTRODUCTION: Type 2 endometrial cancer (T2EC) accounts for 38.7% of all endometrial cancers but is responsible for 74.6% of endometrial cancer deaths. This is potentially due to advanced stage at time of diagnosis. We examine whether social determinants of health are predictors associated with T2EC diagnosed at an advanced stage. METHODS: Retrospective analysis of T2EC cases was performed from May 1, 2015, to March 31, 2022, at one academic site. The primary outcome was advanced stage at time of surgical diagnosis, defined as FIGO stages 3 or 4. Patient age, ethnicity, race (White versus non-White), obesity, and diabetes were evaluated. Multivariate logistic regression model was used to investigate predictors associated with increased risk of advanced-stage disease (ASD), with two-sided P value of <.05 considered significant. RESULTS: A total of 72 patients with T2EC were identified. Thirty-eight (52.7%) cases had early-stage disease and 34 (47.3%) cases had ASD at diagnosis. Ethnicity was the only predictor significantly associated with the primary outcome. Hispanic or Latina ethnicity was associated with 5 times higher odds (odds ratio 5.1, 95% CI 1.2–21.6, P=.028) of ASD at diagnosis, compared to non-Hispanic or Latina. CONCLUSION: Our results show that Hispanic or Latina ethnicity was significantly associated with advanced stage at diagnosis. Non-White race, obesity, diabetes, and age at surgery were not found to be predictors significantly associated with the primary outcome. This could be due to sample size limitations. To facilitate health equity, there is continued need for investigation into the effect of social determinants of health on ASD for T2EC.
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