药粉的流动性:湿度的影响

Daniela Ehgartner, H. Weingrill, Timothy Aschl, D. Schuetz
{"title":"药粉的流动性:湿度的影响","authors":"Daniela Ehgartner, H. Weingrill, Timothy Aschl, D. Schuetz","doi":"10.33892/aph.2021.91.340-341","DOIUrl":null,"url":null,"abstract":"Surrounding conditions impact the behavior of many powders. Depending on the geographical location, bulk solids exhibit differing flowability due to different environmental conditions, e.g. Caracas (30°C, 80 %rH) vs. Boulder/Colorado (25°C, 35 %rH). The powder adjusts dynamically to its environmental condition until reaching saturation at a certain point (1). Besides that, many powders show a “sticky point”. At this point, a significant change in flow and adhesion behavior has been reported (2). Granular media generally tend to increase their cohesive character when surrounded by moisture. This is attributed to several mechanisms whereas formation of adhesive films on the grain surface, liquid bridging between the grains, or if the cohesive behavior decreases, a “lubrication” of the interstitials between grains are considered as the main underlying mechanisms (3). The investigated powder is a pharmaceutical cold and flu hot drink which comprises high amounts of vitamin C, citric acid, sugar and pharmaceutically active materials. The powder exhibits a tendency to cake and time consolidate. This is most likely due to a partial dissolution in condensed water as Groen et al. suggests for a pure citric acid (2). This partial dissolution is desired as the powder is supposed to dissolve in water. As the investigated powder contains a large amount of citric acid as well, a similar “sticky point” is expected. However, this property results in the forming of knots and clumps which is problematic for storage and processing. Thus, the aim of the presented work is to investigate changes in the powder’s flowability behavior after exposure to different relative humidity levels as well as to investigate the difference between consolidated and non-consolidated samples with the help of powder shear cell measurements. 2. Methods","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"10 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Flowability of Pharmaceutical Powders: Impact of Humidity\",\"authors\":\"Daniela Ehgartner, H. Weingrill, Timothy Aschl, D. Schuetz\",\"doi\":\"10.33892/aph.2021.91.340-341\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Surrounding conditions impact the behavior of many powders. Depending on the geographical location, bulk solids exhibit differing flowability due to different environmental conditions, e.g. Caracas (30°C, 80 %rH) vs. Boulder/Colorado (25°C, 35 %rH). The powder adjusts dynamically to its environmental condition until reaching saturation at a certain point (1). Besides that, many powders show a “sticky point”. At this point, a significant change in flow and adhesion behavior has been reported (2). Granular media generally tend to increase their cohesive character when surrounded by moisture. This is attributed to several mechanisms whereas formation of adhesive films on the grain surface, liquid bridging between the grains, or if the cohesive behavior decreases, a “lubrication” of the interstitials between grains are considered as the main underlying mechanisms (3). The investigated powder is a pharmaceutical cold and flu hot drink which comprises high amounts of vitamin C, citric acid, sugar and pharmaceutically active materials. The powder exhibits a tendency to cake and time consolidate. This is most likely due to a partial dissolution in condensed water as Groen et al. suggests for a pure citric acid (2). This partial dissolution is desired as the powder is supposed to dissolve in water. As the investigated powder contains a large amount of citric acid as well, a similar “sticky point” is expected. However, this property results in the forming of knots and clumps which is problematic for storage and processing. Thus, the aim of the presented work is to investigate changes in the powder’s flowability behavior after exposure to different relative humidity levels as well as to investigate the difference between consolidated and non-consolidated samples with the help of powder shear cell measurements. 2. Methods\",\"PeriodicalId\":6941,\"journal\":{\"name\":\"Acta pharmaceutica Hungarica\",\"volume\":\"10 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta pharmaceutica Hungarica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33892/aph.2021.91.340-341\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pharmaceutica Hungarica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33892/aph.2021.91.340-341","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

周围条件影响许多粉末的性能。根据地理位置的不同,散装固体在不同的环境条件下表现出不同的流动性,例如加拉加斯(30°C, 80% rH)与科罗拉多州博尔德(25°C, 35% rH)。粉末动态地适应环境条件,直到达到饱和点(1)。此外,许多粉末还存在“粘点”。在这一点上,已经报道了流动和粘附行为的显著变化(2)。颗粒介质在被水分包围时通常倾向于增加其粘性。这归因于几种机制,而在颗粒表面形成粘附膜,颗粒之间的液体桥接,或者如果粘性行为减少,颗粒之间间隙的“润滑”被认为是主要的潜在机制(3)。所研究的粉末是一种药物感冒和流感热饮,含有大量的维生素C,柠檬酸,糖和药用活性物质。粉末有结块和时间固化的倾向。这很可能是由于在凝结水中部分溶解,正如Groen等人对纯柠檬酸的建议(2)。这种部分溶解是理想的,因为粉末应该溶于水。由于所研究的粉末也含有大量的柠檬酸,因此预计会出现类似的“粘点”。然而,这种特性会导致结和团块的形成,这对存储和处理来说是有问题的。因此,本文的目的是研究暴露于不同相对湿度水平后粉末流动性行为的变化,以及在粉末剪切室测量的帮助下研究固结和非固结样品之间的差异。2. 方法
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flowability of Pharmaceutical Powders: Impact of Humidity
Surrounding conditions impact the behavior of many powders. Depending on the geographical location, bulk solids exhibit differing flowability due to different environmental conditions, e.g. Caracas (30°C, 80 %rH) vs. Boulder/Colorado (25°C, 35 %rH). The powder adjusts dynamically to its environmental condition until reaching saturation at a certain point (1). Besides that, many powders show a “sticky point”. At this point, a significant change in flow and adhesion behavior has been reported (2). Granular media generally tend to increase their cohesive character when surrounded by moisture. This is attributed to several mechanisms whereas formation of adhesive films on the grain surface, liquid bridging between the grains, or if the cohesive behavior decreases, a “lubrication” of the interstitials between grains are considered as the main underlying mechanisms (3). The investigated powder is a pharmaceutical cold and flu hot drink which comprises high amounts of vitamin C, citric acid, sugar and pharmaceutically active materials. The powder exhibits a tendency to cake and time consolidate. This is most likely due to a partial dissolution in condensed water as Groen et al. suggests for a pure citric acid (2). This partial dissolution is desired as the powder is supposed to dissolve in water. As the investigated powder contains a large amount of citric acid as well, a similar “sticky point” is expected. However, this property results in the forming of knots and clumps which is problematic for storage and processing. Thus, the aim of the presented work is to investigate changes in the powder’s flowability behavior after exposure to different relative humidity levels as well as to investigate the difference between consolidated and non-consolidated samples with the help of powder shear cell measurements. 2. Methods
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信