The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Review The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases Peihua Dong , Yu Huang , and Yujie Pu ,* Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 518057 , China * Correspondence: yujiepu@cityu.edu.hk     Received: 29 December 2022 Accepted: 18 January 2023 Published: 10 February 2023   Abstract: Chuanxiong, one of the traditional Chinese medicines (TCM), was first documented in the Tang dynasty to promote blood circulation and remove blood stasis. Ligusticum chuanxiong Hort was shown as the most effective portion of chuanxiong. Later chemical analysis revealed that the main chemical component of ligusticum chuanxiong Hort is tetramethylpyrazine. Since then, numerous explorations have been made to examine the efficiency of tetramethylpyrazine in treating different diseases and understand the underlying mechanisms of its action. Like Chuanxiong, ligustrazine (Chuan Xiong Qin) improved the functions of the circulatory and nervous systems. Ligustrazine (Chuan Xiong Qin) was also used in combination with other medicines to achieve better effects on improving cardiovascular health or alleviating the adverse effects of chemotherapies in both basic and clinical studies. The present review briefly summarizes the existing studies of the combination of ligustrazine (Chuan Xiong Qin) with other medicines in the treatment of cardiovascular diseases (CVDs) and provides valuable insights into the future research direction and better utilization of this drug.