{"title":"古吉拉特邦阿南德Vallabh Vidyanagar地区30 - 50岁成年人群维生素B12水平与生化指标的关系","authors":"Revati Shah, Vinayak Patel, N. Dave","doi":"10.21048/ijnd.2022.59.3.29068","DOIUrl":null,"url":null,"abstract":"Vitamin B12 deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B12 deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B12 deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B12 deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B12 and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B12 deficiency. The subjects were screened for their vitamin B12 status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ? 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ? 0.05) relationship was observed between serum vitamin B12 and iron levels (r = 0.127, P ? 0.05) of the subjects. In conclusion, vitamin B12 status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration","PeriodicalId":22457,"journal":{"name":"The Indian journal of nutrition and dietetics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Vitamin B12 Status with Biochemical Parameters among the Adult Population (30 - 50 Years) of Vallabh Vidyanagar, Anand, Gujarat\",\"authors\":\"Revati Shah, Vinayak Patel, N. Dave\",\"doi\":\"10.21048/ijnd.2022.59.3.29068\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Vitamin B12 deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B12 deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B12 deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B12 deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B12 and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B12 deficiency. The subjects were screened for their vitamin B12 status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ? 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ? 0.05) relationship was observed between serum vitamin B12 and iron levels (r = 0.127, P ? 0.05) of the subjects. In conclusion, vitamin B12 status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration\",\"PeriodicalId\":22457,\"journal\":{\"name\":\"The Indian journal of nutrition and dietetics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Indian journal of nutrition and dietetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21048/ijnd.2022.59.3.29068\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indian journal of nutrition and dietetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21048/ijnd.2022.59.3.29068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
维生素B12缺乏症在素食人群中是非常普遍的,并且由于各种血液学和神经精神疾病而导致高同型半胱氨酸血症。维生素B12缺乏症是一种由吸收不良和摄入不足引起的全球性流行病。维生素B12缺乏对血液和神经系统的影响最大。甲基丙二酸(MMA)和/或总同型半胱氨酸水平升高是维生素B12缺乏的敏感迹象,与临床问题有关。血液学参数,如红细胞计数,血红蛋白浓度或红细胞压积,平均细胞体积(MCV),血液值,如血浆B12和代谢物MMA只是几个例子。从古吉拉特邦阿南德的Vallabh Vidyanagar挑选了398名年龄在30-50岁之间的受试者。42%的研究对象缺乏维生素B12。筛查受试者的维生素B12状态和几个生化参数,如同型半胱氨酸、铁、血红蛋白、总红细胞、PCV、MCV、MCH、MCHC和RDW。发现受试者的总红细胞、MCV、MCH、MCHC水平和同型半胱氨酸浓度显著(P ?0.05)与受试者的维生素B12状况有关。(P ?血清维生素B12与铁水平呈正相关(r = 0.127, P ?0.05)。综上所述,维生素B12水平与总红细胞、MCV、MCH、MCHC水平和同型半胱氨酸浓度显著相关
Association of Vitamin B12 Status with Biochemical Parameters among the Adult Population (30 - 50 Years) of Vallabh Vidyanagar, Anand, Gujarat
Vitamin B12 deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B12 deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B12 deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B12 deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B12 and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B12 deficiency. The subjects were screened for their vitamin B12 status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ? 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ? 0.05) relationship was observed between serum vitamin B12 and iron levels (r = 0.127, P ? 0.05) of the subjects. In conclusion, vitamin B12 status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration