ctDNA分析前过程的质量控制

Q4 Health Professions

中华检验医学杂志 Pub Date : 2020-02-11 DOI:10.3760/CMA.J.ISSN.1009-9158.2020.02.005

Wei Guo

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引用次数: 0

摘要

随着精准肿瘤学的发展，大量临床研究证实了ctDNA在肿瘤治疗中的巨大潜力。然而，ctDNA检测的有效性和通用性仍然受到质疑，阻碍了ctDNA检测临床应用的实现，因此迫切需要制定统一的质量控制标准。标准化的ctDNA分析前分析流程是保证后续分子检测的前提。本文将重点讨论ctDNA分析前分析过程的质量控制因素，以促进ctDNA检测的规范化管理。关键词:循环肿瘤DNA;临床检验技术;质量控制

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Quality control of pre-analytical processes for ctDNA analysis

With the development of precision oncology, a large number of clinical studies have confirmed the great potential of ctDNA in tumor management. However, the effectiveness and versatility of ctDNA detection are still questioned, which hinder the realization of clinical application of ctDNA detection, so there is an urgent need to develop unified quality control standards. The standardized pre-analytical processes for ctDNA analysis are the prerequisite to ensure the subsequent molecular detection. This paper will focus on the factors of quality control of pre-analytical processes for ctDNA analysis, in order to promote the standardized management of ctDNA detection. Key words: Circulating tumor DNA; Clinical laboratory techniques; Quality control

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来源期刊

中华检验医学杂志 Health Professions-Medical Laboratory Technology

CiteScore

0.40

自引率

0.00%

发文量

8037

期刊介绍：