SKIN ANTI-AGEING AND SYSTEMIC REDOX EFFECTS OF SUPPLEMENTATION WITH MARINE COLLAGEN PEPTIDES AND PLANT-DERIVED ANTIOXIDANTS

Recently, development and research of nutraceuticals based on marine collagen peptides (MCPs) have been growing due to their high homology with human collagens, safety, bioavailability through gut, and numerous bio- activities. The major concern regarding safety of MCPs intake relates to increased risk of oxidative stress connected with intense collagen synthesis, and to ROS production by MCPs-stimulated phagocytes. The case- controlled clinical-laboratory study was designed to evaluate skin anti-ageing and systemic redox effects of supplementation with the composition of marine collagen peptides and plant-derived skin-targeting antioxidants (coenzyme Q10+grape skin extract+luteolin+selenium). The data obtained clearly show the improvement of skin properties (elasticity, sebum production, biological age, and dermal ultrasound markers) due to enhanced collagen synthesis without risk of oxidative stress that is usually connected with the synthesis. Metabolic data showed significant increase of plasma hydroxyproline and ATP storage in erythrocytes. Redox parameters, GSH/coenzyme Q10 content, and GPx/GST activities were unchanged, while NO and MDA were moderately increased within, however, normal range of values. The hormesis-like action of the supplementation suggests this mechanism underlying its anti-ageing and energising effects.