{"title":"美洲大蠊苯丙氨酸代谢:酪氨酸和苯甲酰β-葡萄糖苷的生物合成","authors":"L.L. Murdock , T.L. Hopkins, R.A. Wirtz","doi":"10.1016/0010-406X(70)91029-7","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Teneral adult male cockroaches, <em>Periplaneta americana</em>, produced more <sup>14</sup>CO<sub>2</sub> from phenylalanine-1-<sup>14</sup>C than did the mature, fully tanned males. This would indicate utilization of phenylalanine-derived tyrosine for <em>N</em>-acetyl-dopamine biosynthesis during the time of cuticular sclerotization.</p></span></li><li><span>2.</span><span><p>2. Tyrosine biosynthesis from phenylalanine occurred from ecdysis throughout adult life. Less tyrosine accumulated during the teneral period due to increased utilization for cuticular tanning.</p></span></li><li><span>3.</span><span><p>3. A second major metabolite of phenylalanine was benzoic acid, most of which was conjugated as benzoyl-β-glucoside. The glucoside was not produced during the teneral period, suggesting changes in phenylalanine metabolism during ecdysis similar to those of tyrosine.</p></span></li><li><span>4.</span><span><p>4. Phenylpyruvic acid-U-<sup>14</sup>C was rapidly metabolized to phenylalanine and tyrosine, indicating a transaminase in cockroach tissues with the equilibrium of transamination in the direction of the amino acid.</p></span></li></ul></div>","PeriodicalId":78189,"journal":{"name":"Comparative biochemistry and physiology","volume":"36 3","pages":"Pages 535-545"},"PeriodicalIF":0.0000,"publicationDate":"1970-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0010-406X(70)91029-7","citationCount":"8","resultStr":"{\"title\":\"Phenylalanine metabolism in cockroaches, Periplaneta americana: Tyrosine and benzoyl-β-glucoside biosynthesis\",\"authors\":\"L.L. Murdock , T.L. Hopkins, R.A. Wirtz\",\"doi\":\"10.1016/0010-406X(70)91029-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Teneral adult male cockroaches, <em>Periplaneta americana</em>, produced more <sup>14</sup>CO<sub>2</sub> from phenylalanine-1-<sup>14</sup>C than did the mature, fully tanned males. This would indicate utilization of phenylalanine-derived tyrosine for <em>N</em>-acetyl-dopamine biosynthesis during the time of cuticular sclerotization.</p></span></li><li><span>2.</span><span><p>2. Tyrosine biosynthesis from phenylalanine occurred from ecdysis throughout adult life. Less tyrosine accumulated during the teneral period due to increased utilization for cuticular tanning.</p></span></li><li><span>3.</span><span><p>3. A second major metabolite of phenylalanine was benzoic acid, most of which was conjugated as benzoyl-β-glucoside. The glucoside was not produced during the teneral period, suggesting changes in phenylalanine metabolism during ecdysis similar to those of tyrosine.</p></span></li><li><span>4.</span><span><p>4. Phenylpyruvic acid-U-<sup>14</sup>C was rapidly metabolized to phenylalanine and tyrosine, indicating a transaminase in cockroach tissues with the equilibrium of transamination in the direction of the amino acid.</p></span></li></ul></div>\",\"PeriodicalId\":78189,\"journal\":{\"name\":\"Comparative biochemistry and physiology\",\"volume\":\"36 3\",\"pages\":\"Pages 535-545\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1970-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0010-406X(70)91029-7\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0010406X70910297\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0010406X70910297","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
摘要
1.1. 一般的成年雄蟑螂，美洲大蠊，比完全晒黑的成年雄蟑螂产生更多的苯丙氨酸-1- 14c。这表明在角质层硬化过程中，苯丙氨酸衍生的酪氨酸被用于n -乙酰基多巴胺的生物合成。苯丙氨酸生物合成酪氨酸的过程贯穿于整个成年期。由于角质层鞣制的利用率增加，在一般时期积累的酪氨酸较少。苯丙氨酸的第二个主要代谢物是苯甲酸，其中大部分被偶联为苯甲酰-β-葡萄糖苷。4.4.在发酵过程中，苯丙氨酸的代谢变化与酪氨酸相似。苯基丙酮酸- u - 14c迅速代谢为苯丙氨酸和酪氨酸，表明在蟑螂组织中存在转氨酶，且转氨酶向氨基酸方向平衡。
Phenylalanine metabolism in cockroaches, Periplaneta americana: Tyrosine and benzoyl-β-glucoside biosynthesis
1.
1. Teneral adult male cockroaches, Periplaneta americana, produced more 14CO2 from phenylalanine-1-14C than did the mature, fully tanned males. This would indicate utilization of phenylalanine-derived tyrosine for N-acetyl-dopamine biosynthesis during the time of cuticular sclerotization.
2.
2. Tyrosine biosynthesis from phenylalanine occurred from ecdysis throughout adult life. Less tyrosine accumulated during the teneral period due to increased utilization for cuticular tanning.
3.
3. A second major metabolite of phenylalanine was benzoic acid, most of which was conjugated as benzoyl-β-glucoside. The glucoside was not produced during the teneral period, suggesting changes in phenylalanine metabolism during ecdysis similar to those of tyrosine.
4.
4. Phenylpyruvic acid-U-14C was rapidly metabolized to phenylalanine and tyrosine, indicating a transaminase in cockroach tissues with the equilibrium of transamination in the direction of the amino acid.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
