S. Aslam, F. Hussain, N. Sattar, K. Gillespie, N. Shafiq, S. Shaheen, Siraj-udin Sajid, Sobia Aleem
{"title":"维生素D受体(VDR)基因多态性在2型糖尿病发病中的作用","authors":"S. Aslam, F. Hussain, N. Sattar, K. Gillespie, N. Shafiq, S. Shaheen, Siraj-udin Sajid, Sobia Aleem","doi":"10.31248/JBBD2018.077","DOIUrl":null,"url":null,"abstract":"Numerous studies disclosed the independent role of VDR genetic polymorphisms involved in pathogenesies of various metabolic disorders like type 2 diabetes mellitus in different populations, however no any conclusive or even key study conducted on South Asian population especially Pakistani population except on Indian population. Worldwidle, vitamin D defeciency and type 2 diabetes mellitus (T2DM) are two interlated and most common health problems. Such interlationship is involved complex inheritance pattern.The polymorphisms of various genes including vitamin D receptor (VDR) might affect genetic susceptibility of T2DM by developing malfunctioning of beta pancreatic cells or insulin resistance. Genetic architecture of T2DM is different among various ethnic populations. The present review will focus on concept that polymorphism of VDR gene may has role in susceptibilty of onset of T2DM and its pathogenesises.","PeriodicalId":15121,"journal":{"name":"Journal of Bioscience and Biotechnology Discovery","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Role of vitamin D receptor (VDR) genetic polymorphism in onset of type 2 diabetes mellitus: A Review\",\"authors\":\"S. Aslam, F. Hussain, N. Sattar, K. Gillespie, N. Shafiq, S. Shaheen, Siraj-udin Sajid, Sobia Aleem\",\"doi\":\"10.31248/JBBD2018.077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Numerous studies disclosed the independent role of VDR genetic polymorphisms involved in pathogenesies of various metabolic disorders like type 2 diabetes mellitus in different populations, however no any conclusive or even key study conducted on South Asian population especially Pakistani population except on Indian population. Worldwidle, vitamin D defeciency and type 2 diabetes mellitus (T2DM) are two interlated and most common health problems. Such interlationship is involved complex inheritance pattern.The polymorphisms of various genes including vitamin D receptor (VDR) might affect genetic susceptibility of T2DM by developing malfunctioning of beta pancreatic cells or insulin resistance. Genetic architecture of T2DM is different among various ethnic populations. The present review will focus on concept that polymorphism of VDR gene may has role in susceptibilty of onset of T2DM and its pathogenesises.\",\"PeriodicalId\":15121,\"journal\":{\"name\":\"Journal of Bioscience and Biotechnology Discovery\",\"volume\":\"29 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Bioscience and Biotechnology Discovery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31248/JBBD2018.077\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bioscience and Biotechnology Discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31248/JBBD2018.077","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of vitamin D receptor (VDR) genetic polymorphism in onset of type 2 diabetes mellitus: A Review
Numerous studies disclosed the independent role of VDR genetic polymorphisms involved in pathogenesies of various metabolic disorders like type 2 diabetes mellitus in different populations, however no any conclusive or even key study conducted on South Asian population especially Pakistani population except on Indian population. Worldwidle, vitamin D defeciency and type 2 diabetes mellitus (T2DM) are two interlated and most common health problems. Such interlationship is involved complex inheritance pattern.The polymorphisms of various genes including vitamin D receptor (VDR) might affect genetic susceptibility of T2DM by developing malfunctioning of beta pancreatic cells or insulin resistance. Genetic architecture of T2DM is different among various ethnic populations. The present review will focus on concept that polymorphism of VDR gene may has role in susceptibilty of onset of T2DM and its pathogenesises.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
