斑秃的循证治疗

A. Al-Shammari, Qusay Jassam Shandookh
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引用次数: 0

摘要

雄激素性脱发(AGA)被认为是主要的非瘢痕性脱发,导致进行性毛囊小型化。在很大程度上,一个人的基因构成和荷尔蒙环境决定了他们的头皮末梢毛是否会变成牛皮毛。随着人们年龄的增长,AGA变得越来越普遍。AGA是一种进行性疾病,其特点是生长期缩短,休止期维持。患有AGA的女性倾向于看到更多的弥漫性脱发,而患有AGA的男性倾向于在顶点附近变薄。AGA的金标准治疗方法是米诺地尔(局部使用)和非那雄胺(一种口服5α-还原酶抑制剂II型抑制剂),它们是迄今为止美国食品和药物管理局(FDA)唯一接受的药物。AGA现有疗法的成功与否经常受到质疑,这使得发现治疗这种疾病的新疗法变得至关重要。为了减缓这种疾病的进程并促进其结果,本文将研究用于识别AGA的原因和诊断工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evidence Based Treatments of Alopecia Areata
Androgenetic Alopecia (AGA) is considered as major non-cicatricial alopecia which causes progressive hair follicle miniaturization. To a large extent, a person's genetic makeup and hormonal environment determine whether or not their terminal scalp hairs will be transformed into vellus hairs. AGA becomes more common and commoner as people get older. AGA is a progressive disorder characterized by a shortening of the anagen phase and maintenance of the telogen phase. Females with AGA tend to see more diffuse hair loss over the head, while males with AGA tend to experience thinning near the vertex. The gold standard treatments for AGA are minoxidil (used topically) and finasteride (an oral 5α-reductase inhibitor type II inhibitor) and they are the only medications accepted by the Food and Drug Administration (FDA) to date. The success of existing therapy for AGA is frequently questioned, making the discovery of new therapeutics for this illness of critical importance. In an effort to slow the disease's course and boost its outcomes, this article will examine the causes and diagnostic tools used to identify AGA.
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