多次呼吸冲洗分析:模拟导气管不对称的影响

Merryn Howatson Tawhai, Peter J Hunter
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引用次数: 48

摘要

利用人体肺的数学模型研究了呼吸和传导气道不对称、气体交换和不均匀通气对气体冲刷曲线III期肺泡平台倾斜的贡献。模型范围从完全对称到详细的不对称传导气道模型,再加上29445个集总参数呼吸道模型。用拉格朗日-伽辽金方法求解了模型中的气体输运方程。肺泡斜率由平均气体浓度归一化得到Sn。模型结果证实,第一次呼吸Sn主要受到呼吸道不对称的影响,在接近正常通气水平时,传导气道不对称对Sn的进一步增加起着重要作用。气体交换缓和了Sn与呼吸次数的关系,使其在以后的呼吸中趋于平稳。非均匀流动也改变了Sn,表明准确描述胸膜压力梯度对于更精确的模拟是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multibreath washout analysis: modelling the influence of conducting airway asymmetry

The contributions of respiratory and conducting airway asymmetry, gas exchange, and non-uniform ventilation to the sloping alveolar plateau in phase III of the gas washout curve are investigated using mathematical models of the human lung. The models range from fully symmetric, to a detailed asymmetric conducting airway model coupled with 29 445 lumped parameter respiratory airway models. A gas transport equation is solved in the models using a Lagrange-Galerkin method. The alveolar slope is normalised by the mean expired gas concentration to give Sn. The model results confirm that first breath Sn is influenced mainly by respiratory airway asymmetry, and that at near-normal levels of ventilation the conducting airway asymmetry contributes a significant amount to further increases in Sn. Gas exchange moderates the plot of Sn against breath number, such that it approaches a plateau in later breaths. Non-uniform flow also alters Sn, indicating that an accurate description of the pleural pressure gradient will be necessary for more accurate simulations.

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