慢性心力衰竭患者凝血系统的变化

Y. Ovchinnikov, M. B. Patsenko, N. Gulyaev, M. A. Lebedev
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引用次数: 0

摘要

本文综述了有关慢性心力衰竭(CHF)患者止血系统研究的科学出版物。俄罗斯和国外作者评估了CHF患者出血和血栓形成的风险,以及凝血系统个体标志物和因子含量的变化。审查表明,获得的结果是相当矛盾的。一方面,数据显示血栓形成的风险增加,一些内皮标记物的含量改变,促进内皮血栓形成,血小板聚集标记物的含量增加,血凝素和凝血酶水平升高。另一方面,有数据表明CHF患者出血风险增加,一些内皮标志物的增加增强了内皮的抗凝特性。从所做的分析可以看出,这一课题的研究还不够充分,目前很难判断CHF患者的止血潜能。血栓弹性成像(TEG)和低频压电血栓弹性成像(LF-PTEG)等综合方法的应用是研究这一问题的一个有前途的方向。使用这些方法获得的结果可能允许更精确地了解CHF患者凝血系统功能的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in the blood coagulation system in patients with chronic heart failure
The article provides a review of scientifi c publications dedicated to the study of the hemostatic system in patients with chronic heart failure (CHF). Russian and foreign authors evaluated the risks of bleeding and thrombosis in patients with CHF, as well as changes in the content of individual markers and factors of the coagulation system. The review suggests that the results obtained are quite contradictory. On the one hand, data is presented on an increased risk of thrombosis, changes in the content of some endothelial markers that promote endothelial thrombogenicity, an increase in the content of platelet aggregation markers, and elevated levels of fi brinogen and thrombin. On the other hand, there is data on an increased risk of bleeding in patients with CHF, an increase in some endothelial markers that enhance the anticoagulant properties of the endothelium. From the analysis conducted, it can be concluded that this topic is not suffi  ciently studied, and it is diffi  cult to judge the hemostatic potential in patients with CHF at present. The use of integrated methods such as thromboelastography (TEG) and low-frequency piezothromboelastography (LF-PTEG) are a promising direction for studying this problem. The results obtained using these methods will likely allow for a more precise understanding of the features of the coagulation system functioning in patients with CHF.
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