{"title":"肾促红细胞生成素分泌是局部缺氧与血管生成局部抑制的结果吗?","authors":"Beatrica Kurbel , Sven Kurbel","doi":"10.1016/j.bihy.2008.03.007","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The kidney is a major source of systemic erythropoietin, despite itself showing little </span>angiogenesis. Based on paper by Schumacher VA et-al. [J Am Soc Nephrol 2007;18:719–29] that renal synthesis of an inhibitory VEGF variant (VEGF165b) blocks local angiogenesis, we hypothesise that the chronic hypoxia in the renal medulla, due to limited perfusion through </span><span><em>vasa </em><em>recta</em></span> stimulates continuous renal erythropoietin secretion.</p></div>","PeriodicalId":87894,"journal":{"name":"Bioscience hypotheses","volume":"2 1","pages":"Pages 50-51"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bihy.2008.03.007","citationCount":"0","resultStr":"{\"title\":\"Is renal erythropoietin secretion consequence of local hypoxia coupled with local suppression of angiogenesis?\",\"authors\":\"Beatrica Kurbel , Sven Kurbel\",\"doi\":\"10.1016/j.bihy.2008.03.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>The kidney is a major source of systemic erythropoietin, despite itself showing little </span>angiogenesis. Based on paper by Schumacher VA et-al. [J Am Soc Nephrol 2007;18:719–29] that renal synthesis of an inhibitory VEGF variant (VEGF165b) blocks local angiogenesis, we hypothesise that the chronic hypoxia in the renal medulla, due to limited perfusion through </span><span><em>vasa </em><em>recta</em></span> stimulates continuous renal erythropoietin secretion.</p></div>\",\"PeriodicalId\":87894,\"journal\":{\"name\":\"Bioscience hypotheses\",\"volume\":\"2 1\",\"pages\":\"Pages 50-51\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bihy.2008.03.007\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioscience hypotheses\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1756239208001328\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience hypotheses","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756239208001328","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Is renal erythropoietin secretion consequence of local hypoxia coupled with local suppression of angiogenesis?
The kidney is a major source of systemic erythropoietin, despite itself showing little angiogenesis. Based on paper by Schumacher VA et-al. [J Am Soc Nephrol 2007;18:719–29] that renal synthesis of an inhibitory VEGF variant (VEGF165b) blocks local angiogenesis, we hypothesise that the chronic hypoxia in the renal medulla, due to limited perfusion through vasa recta stimulates continuous renal erythropoietin secretion.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
