Julien Martinez, Gaspar Bruner-Montero, Ramesh Arunkumar, Sophia C L Smith, Jonathan P Day, Ben Longdon, Francis M Jiggins
{"title":"受狼巴西亚病毒感染果蝇的病毒进化。","authors":"Julien Martinez, Gaspar Bruner-Montero, Ramesh Arunkumar, Sophia C L Smith, Jonathan P Day, Ben Longdon, Francis M Jiggins","doi":"10.1098/rspb.2019.2117","DOIUrl":null,"url":null,"abstract":"<p><p><i>Wolbachia</i>, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, <i>Wolbachia-</i>infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programmes is whether viruses can evolve to escape the antiviral effects of <i>Wolbachia.</i> We have found that <i>Wolbachia</i> altered the outcome of competition between strains of the DCV virus in <i>Drosophila.</i> However, <i>Wolbachia</i> still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that <i>Wolbachia</i> did cause an evolutionary response in viruses, but this has little or no impact on the effectiveness of virus blocking.</p>","PeriodicalId":20609,"journal":{"name":"Proceedings of the Royal Society B","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823055/pdf/","citationCount":"0","resultStr":"{\"title\":\"Virus evolution in <i>Wolbachia-</i>infected <i>Drosophila</i>.\",\"authors\":\"Julien Martinez, Gaspar Bruner-Montero, Ramesh Arunkumar, Sophia C L Smith, Jonathan P Day, Ben Longdon, Francis M Jiggins\",\"doi\":\"10.1098/rspb.2019.2117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Wolbachia</i>, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, <i>Wolbachia-</i>infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programmes is whether viruses can evolve to escape the antiviral effects of <i>Wolbachia.</i> We have found that <i>Wolbachia</i> altered the outcome of competition between strains of the DCV virus in <i>Drosophila.</i> However, <i>Wolbachia</i> still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that <i>Wolbachia</i> did cause an evolutionary response in viruses, but this has little or no impact on the effectiveness of virus blocking.</p>\",\"PeriodicalId\":20609,\"journal\":{\"name\":\"Proceedings of the Royal Society B\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823055/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Royal Society B\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1098/rspb.2019.2117\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/10/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Royal Society B","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1098/rspb.2019.2117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/10/30 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Wolbachia, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, Wolbachia-infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programmes is whether viruses can evolve to escape the antiviral effects of Wolbachia. We have found that Wolbachia altered the outcome of competition between strains of the DCV virus in Drosophila. However, Wolbachia still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that Wolbachia did cause an evolutionary response in viruses, but this has little or no impact on the effectiveness of virus blocking.