疟疾感染的脑和肝葡萄糖利用不依赖于疾病的脑症状

IF 0.4 4区化学 Q4 CHEMISTRY, PHYSICAL

Concepts in Magnetic Resonance Part A Pub Date : 2019-12-19 DOI:10.1155/2019/3542393

Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, H. M. Sonawat

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引用次数: 1

摘要

脑疟疾每年造成数人死亡。全球代谢改变，特别是低血糖和乳酸性酸中毒是严重疟疾的标志。葡萄糖是大脑的主要燃料来源，了解宿主在脑并发症期间脑葡萄糖的利用可能在脑发病机制中起重要作用。我们利用13C核磁共振光谱研究了脑型疟疾(CM)、非脑型疟疾(NCM)和对照小鼠脑和肝脏中葡萄糖的利用情况。小鼠接受静脉注射葡萄糖，然后对脑和肝脏提取物进行代谢分析。我们的结果表明，疟疾组的葡萄糖利用率与对照组不同，而CM和NCM之间没有差异。

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Brain and Hepatic Glucose Utilization in Malarial Infection Does Not Depend on Cerebral Symptoms of the Disease

Cerebral malaria causes several deaths every year. Global metabolic alteration, specifically hypoglycemia and lactic acidosis are hallmarks of severe malaria. Glucose being the major fuel source for the brain, it is important to understand cerebral glucose utilization in the host during cerebral complications of the disease that may have a significant role in cerebral pathogenesis. We have used 13C NMR spectroscopy to understand glucose utilization in the brain and liver of mice with cerebral malaria (CM), noncerebral malaria (NCM), and in control mice. Animals were challenged with intravenous glucose bolus followed by metabolic profiling of brain and liver extracts. Our result suggests a differential glucose utilization in the malaria group with respect to that of controls, while no difference between CM and NCM.

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来源期刊

Concepts in Magnetic Resonance Part A 物理-光谱学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Concepts in Magnetic Resonance Part A brings together clinicians, chemists, and physicists involved in the application of magnetic resonance techniques. The journal welcomes contributions predominantly from the fields of magnetic resonance imaging (MRI), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR), but also encourages submissions relating to less common magnetic resonance imaging and analytical methods. Contributors come from academic, governmental, and clinical communities, to disseminate the latest important experimental results from medical, non-medical, and analytical magnetic resonance methods, as well as related computational and theoretical advances. Subject areas include (but are by no means limited to): -Fundamental advances in the understanding of magnetic resonance -Experimental results from magnetic resonance imaging (including MRI and its specialized applications) -Experimental results from magnetic resonance spectroscopy (including NMR, EPR, and their specialized applications) -Computational and theoretical support and prediction for experimental results -Focused reviews providing commentary and discussion on recent results and developments in topical areas of investigation -Reviews of magnetic resonance approaches with a tutorial or educational approach