{"title":"自由基在生物催化中的形成机制","authors":"Marc Fontecave , Jean-Louis Pierre","doi":"10.1016/S1387-1609(01)01283-X","DOIUrl":null,"url":null,"abstract":"<div><p>A large number of selective metabolic reactions involve intermediate free radicals. To do so, enzymatic systems rely upon a great variety of efficient radical sources, such as adenosylcobalamin, <em>S</em>-adenosylmethionine and oxygen for reaction initiation. In most cases, activation depends on a metallocofactor. The review article focuses on some of these chemical mechanisms for biological radical generation.</p></div>","PeriodicalId":100305,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","volume":"4 7","pages":"Pages 531-538"},"PeriodicalIF":0.0000,"publicationDate":"2001-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1387-1609(01)01283-X","citationCount":"6","resultStr":"{\"title\":\"Mechanisms of formation of free radicals in biological catalysis\",\"authors\":\"Marc Fontecave , Jean-Louis Pierre\",\"doi\":\"10.1016/S1387-1609(01)01283-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A large number of selective metabolic reactions involve intermediate free radicals. To do so, enzymatic systems rely upon a great variety of efficient radical sources, such as adenosylcobalamin, <em>S</em>-adenosylmethionine and oxygen for reaction initiation. In most cases, activation depends on a metallocofactor. The review article focuses on some of these chemical mechanisms for biological radical generation.</p></div>\",\"PeriodicalId\":100305,\"journal\":{\"name\":\"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry\",\"volume\":\"4 7\",\"pages\":\"Pages 531-538\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1387-1609(01)01283-X\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S138716090101283X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138716090101283X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mechanisms of formation of free radicals in biological catalysis
A large number of selective metabolic reactions involve intermediate free radicals. To do so, enzymatic systems rely upon a great variety of efficient radical sources, such as adenosylcobalamin, S-adenosylmethionine and oxygen for reaction initiation. In most cases, activation depends on a metallocofactor. The review article focuses on some of these chemical mechanisms for biological radical generation.
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