高分子纳米颗粒在肿瘤治疗中的应用综述

S. Thakur, Pramod Ks, R. Malviya
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引用次数: 14

摘要

医学和生物技术的快速发展推动了药物发现领域的发展。新方法的药物输送,如配制聚合物纳米粒子是革命性的药物的未来。新的强效和靶向性药物提高了治疗效果。这些挑战,加上复杂性和多样性,正在推动克服生物利用度和递送障碍的新型药物递送系统的进步。在目前的情况下,纳米颗粒已经作为载体,以提供广泛的潜在药物。由于它们的多功能性和广泛的性质,它们代表了一种有前途的控制和靶向释放的药物传递系统。利用聚合纳米颗粒是一种旨在减少不良反应和优化治疗效果的计划。纳米粒子为癌症患者提供安全有效的治疗。纳米医学技术的进步提供了明确的证据,聚合物纳米治疗在肿瘤学中具有重要的影响。本文重点介绍了高分子纳米颗粒系统在治疗方面的应用。本文综述了高分子纳米粒子体系、纳米粒子的命运、类型、靶向机制、应用和最新专利。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Utilization of Polymeric Nanoparticle in Cancer Treatment: A Review
Rapid advancement in medicine and biotechnology has driven the field of drug discovery. Novel approaches of drug delivery such as formulating the polymeric nanoparticles is revolutionizing the future of medicines. Newly potent and target specific drugs led to enhance therapeutic utility. These challenges, coupled with the complexity and variety, are fueling the advancement of novel drug delivery systems that overcome bioavailability and delivery obstacles. In present scenario, nanoparticles have been acting as carriers for delivering a wide range of potential drugs. Due to their versatility and wide range of properties and they represent a promising drug delivery system of controlled and targeted release. The utilization of polymeric nanoparticles is a plan that aims to minimize adverse effect and will optimize therapeutic effects. Nanoparticle-based therapy facilitates safe and efficacious therapy for cancer patients. Advancement in Nanomedicine technologies provides clear evidence that polymeric nanotherapies have a significant impact in oncology. Improvement in therapeutic utility of polymeric nano-particulate system is highlighted in this paper. This review deals with the polymeric nanoparticulate systems, fate of nanoparticles, its types, targetting mechanism, application and recent patents.
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