绝经前妇女急性冠脉综合征与性激素关系的研究

Veena Nanjappa, Hema Raveesh, Ashwini Kuldeep, Sadanand K. S, M. C. N
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引用次数: 0

摘要

高睾酮和低雌激素水平与女性心血管疾病有关。然而,内源性性激素与绝经前妇女急性冠脉综合征(ACS)的关系研究较少。我们研究了50名患有ACS的绝经前妇女和年龄匹配的对照组,她们同意研究睾酮、雌二醇和性激素结合球蛋白(SHBG)的基线水平。临床随访6个月。平均年龄37.42±5.7岁。48%的患者肥胖。平均体重指数为27.53±5.41 kg/m2。高血压是最常见的危险因素,其次是糖尿病。14%有冠心病(CAD)家族史。24%的患者在就诊时有不典型胸痛。前壁ST段抬高型心肌梗死是最常见的表现。单血管病变占38%;24%为非阻塞性CAD。在病例和对照组中分析生物有效睾酮:雌二醇、雌二醇:低密度脂蛋白(LDL)、雌二醇:高密度脂蛋白、SHBG: LDL和SHBG: HbA1c的比值,均未发现显著相关。内源性性激素未发现与绝经前妇女ACS显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of Acute Coronary Syndrome in Premenopausal Women in Correlation with Sex Hormones
Higher testosterone and lower Estrogen levels are associated with cardiovascular disease in women. However, studies on endogenous sex hormones and acute coronary syndrome (ACS) in pre-menopausal women are sparse. We studied 50 pre-menopausal women presenting with ACS and age-matched controls who consented to the study with Testosterone, Estradiol, and Sex hormone-binding globulin (SHBG) levels at baseline. They were clinically followed up for 6 months duration. The mean age was 37.42 ± 5.7 years. 48% patients were obese. The mean body mass index was 27.53 ± 5.41 kg/m2. Hypertension followed by Diabetes was the most common risk factor. 14% had family history of coronary artery disease (CAD). 24% had atypical chest pain at presentation. Anterior wall ST elevation myocardial infarction was the most common presentation. Single-vessel disease was seen in 38%; 24% had Non-Obstructive CAD. Ratios of Bioavailable Testosterone: Estradiol, Estradiol: Low-density Lipoprotein (LDL), Estradiol: High-density Lipoprotein, SHBG: LDL, and SHBG: HbA1c were analyzed in cases and controls and were not found to be significantly associated. Endogenous sex hormones were not found to be significantly associated with ACS in premenopausal women.
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