自组装纳米粒子与集成光电二极管的DNA检测

Proceedings of IEEE Sensors, 2004. Pub Date : 2004-01-01 DOI:10.1109/ICSENS.2004.1426355

Jiong Li, Chen Xu, Zhikuan Zhang, Yijin Wang, H. Peng, Zuhong Lu, M. Chan

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引用次数: 0

摘要

提出了一种基于自组装纳米金属粒子与普通可见光相互作用的兼容硅集成电路(IC)的DNA检测平台。DNA杂交引发在支撑体表面形成不透明区域。然后，在支撑表面下方制作光电二极管阵列，用于检测纳米颗粒组装前后的光强变化;信号可以通过银增强进一步放大。

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DNA detection by self-assembled nano-particle and integrated photodiodes

We propose a silicon integrated circuit (IC) compatible DNA detection platform based on the interaction of self-assembled nano-metallic particles and ordinary visible light. The DNA hybridization initiates the formation of an opaque area at the surface of the support. A photodiode array fabricated underneath the supporting surface can then be used to detect the light intensity changes before and after the assembly of the nano-particle; the signal can be further amplified by silver enhancement.

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Proceedings of IEEE Sensors, 2004.

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