{"title":"根据目前的 CD4 T 淋巴细胞计数，对接受抗逆转录病毒疗法的人类免疫缺陷病毒感染者接种严重急性呼吸系统综合征冠状病毒 2 (SARS-CoV-2) mRNA 疫苗引起的体液和细胞免疫反应。","authors":"Andrea Antinori, Stefania Cicalini, Silvia Meschi, Veronica Bordoni, Patrizia Lorenzini, Alessandra Vergori, Simone Lanini, Lidya De Pascale, Giulia Matusali, Davide Mariotti, Alessandro Cozzi Lepri, Paola Gallì, Carmela Pinnetti, Roberta Gagliardini, Valentina Mazzotta, Ilaria Mastrorosa, Susanna Grisetti, Francesca Colavita, Eleonora Cimini, Elisabetta Grilli, Rita Bellagamba, Daniele Lapa, Alessandra Sacchi, Alessandra Marani, Carlo Cerini, Caterina Candela, Marisa Fusto, Vincenzo Puro, Concetta Castilletti, Chiara Agrati, Enrico Girardi, Francesco Vaia","doi":"10.1093/cid/ciac238","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Data on SARS-CoV-2 vaccine immunogenicity in PLWH are currently limited. Aim of the study was to investigate immunogenicity according to current CD4 T-cell count.</p><p><strong>Methods: </strong>PLWH on ART attending a SARS-CoV-2 vaccination program, were included in a prospective immunogenicity evaluation after receiving BNT162b2 or mRNA-1273. Participants were stratified by current CD4 T-cell count (poor CD4 recovery, PCDR: <200/mm3; intermediate CD4 recovery, ICDR: 200-500/mm3; high CD4 recovery, HCDR: >500/mm3). RBD-binding IgG, SARS-CoV-2 neutralizing antibodies (nAbs) and IFN-γ release were measured. As control group, HIV-negative healthcare workers (HCWs) were used.</p><p><strong>Findings: </strong>Among 166 PLWH, after 1 month from the booster dose, detectable RBD-binding IgG were elicited in 86.7% of PCDR, 100% of ICDR, 98.7% of HCDR, and a neutralizing titre ≥1:10 elicited in 70.0%, 88.2%, and 93.1%, respectively. Compared to HCDR, all immune response parameters were significantly lower in PCDR. After adjusting for confounders, current CD4 T-cell <200/mm3 significantly predicted a poor magnitude of anti-RDB, nAbs and IFN-γ response. As compared with HCWs, PCDR elicited a consistently reduced immunogenicity for all parameters, ICDR only a reduced RBD-binding antibody response, whereas HCDR elicited a comparable immune response for all parameters.</p><p><strong>Conclusion: </strong>Humoral and cell-mediated immune response against SARS-CoV-2 were elicited in most of PLWH, albeit significantly poorer in those with CD4 T-cell <200/mm3 versus those with >500 cell/mm3 and HIV-negative controls. A lower RBD-binding antibody response than HCWs was also observed in PLWH with CD4 T-cell 200-500/mm3, whereas immune response elicited in PLWH with a CD4 T-cell >500/mm3 was comparable to HIV-negative population.</p>","PeriodicalId":11199,"journal":{"name":"Diatom Research","volume":"21 1","pages":"e552-e563"},"PeriodicalIF":1.9000,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047161/pdf/","citationCount":"0","resultStr":"{\"title\":\"Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count.\",\"authors\":\"Andrea Antinori, Stefania Cicalini, Silvia Meschi, Veronica Bordoni, Patrizia Lorenzini, Alessandra Vergori, Simone Lanini, Lidya De Pascale, Giulia Matusali, Davide Mariotti, Alessandro Cozzi Lepri, Paola Gallì, Carmela Pinnetti, Roberta Gagliardini, Valentina Mazzotta, Ilaria Mastrorosa, Susanna Grisetti, Francesca Colavita, Eleonora Cimini, Elisabetta Grilli, Rita Bellagamba, Daniele Lapa, Alessandra Sacchi, Alessandra Marani, Carlo Cerini, Caterina Candela, Marisa Fusto, Vincenzo Puro, Concetta Castilletti, Chiara Agrati, Enrico Girardi, Francesco Vaia\",\"doi\":\"10.1093/cid/ciac238\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Data on SARS-CoV-2 vaccine immunogenicity in PLWH are currently limited. Aim of the study was to investigate immunogenicity according to current CD4 T-cell count.</p><p><strong>Methods: </strong>PLWH on ART attending a SARS-CoV-2 vaccination program, were included in a prospective immunogenicity evaluation after receiving BNT162b2 or mRNA-1273. Participants were stratified by current CD4 T-cell count (poor CD4 recovery, PCDR: <200/mm3; intermediate CD4 recovery, ICDR: 200-500/mm3; high CD4 recovery, HCDR: >500/mm3). RBD-binding IgG, SARS-CoV-2 neutralizing antibodies (nAbs) and IFN-γ release were measured. As control group, HIV-negative healthcare workers (HCWs) were used.</p><p><strong>Findings: </strong>Among 166 PLWH, after 1 month from the booster dose, detectable RBD-binding IgG were elicited in 86.7% of PCDR, 100% of ICDR, 98.7% of HCDR, and a neutralizing titre ≥1:10 elicited in 70.0%, 88.2%, and 93.1%, respectively. Compared to HCDR, all immune response parameters were significantly lower in PCDR. After adjusting for confounders, current CD4 T-cell <200/mm3 significantly predicted a poor magnitude of anti-RDB, nAbs and IFN-γ response. As compared with HCWs, PCDR elicited a consistently reduced immunogenicity for all parameters, ICDR only a reduced RBD-binding antibody response, whereas HCDR elicited a comparable immune response for all parameters.</p><p><strong>Conclusion: </strong>Humoral and cell-mediated immune response against SARS-CoV-2 were elicited in most of PLWH, albeit significantly poorer in those with CD4 T-cell <200/mm3 versus those with >500 cell/mm3 and HIV-negative controls. A lower RBD-binding antibody response than HCWs was also observed in PLWH with CD4 T-cell 200-500/mm3, whereas immune response elicited in PLWH with a CD4 T-cell >500/mm3 was comparable to HIV-negative population.</p>\",\"PeriodicalId\":11199,\"journal\":{\"name\":\"Diatom Research\",\"volume\":\"21 1\",\"pages\":\"e552-e563\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2022-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047161/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diatom Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/cid/ciac238\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MARINE & FRESHWATER BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diatom Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/cid/ciac238","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MARINE & FRESHWATER BIOLOGY","Score":null,"Total":0}
Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count.
Background: Data on SARS-CoV-2 vaccine immunogenicity in PLWH are currently limited. Aim of the study was to investigate immunogenicity according to current CD4 T-cell count.
Methods: PLWH on ART attending a SARS-CoV-2 vaccination program, were included in a prospective immunogenicity evaluation after receiving BNT162b2 or mRNA-1273. Participants were stratified by current CD4 T-cell count (poor CD4 recovery, PCDR: <200/mm3; intermediate CD4 recovery, ICDR: 200-500/mm3; high CD4 recovery, HCDR: >500/mm3). RBD-binding IgG, SARS-CoV-2 neutralizing antibodies (nAbs) and IFN-γ release were measured. As control group, HIV-negative healthcare workers (HCWs) were used.
Findings: Among 166 PLWH, after 1 month from the booster dose, detectable RBD-binding IgG were elicited in 86.7% of PCDR, 100% of ICDR, 98.7% of HCDR, and a neutralizing titre ≥1:10 elicited in 70.0%, 88.2%, and 93.1%, respectively. Compared to HCDR, all immune response parameters were significantly lower in PCDR. After adjusting for confounders, current CD4 T-cell <200/mm3 significantly predicted a poor magnitude of anti-RDB, nAbs and IFN-γ response. As compared with HCWs, PCDR elicited a consistently reduced immunogenicity for all parameters, ICDR only a reduced RBD-binding antibody response, whereas HCDR elicited a comparable immune response for all parameters.
Conclusion: Humoral and cell-mediated immune response against SARS-CoV-2 were elicited in most of PLWH, albeit significantly poorer in those with CD4 T-cell <200/mm3 versus those with >500 cell/mm3 and HIV-negative controls. A lower RBD-binding antibody response than HCWs was also observed in PLWH with CD4 T-cell 200-500/mm3, whereas immune response elicited in PLWH with a CD4 T-cell >500/mm3 was comparable to HIV-negative population.
期刊介绍：
Diatom Research is the journal of the International Society for Diatom Research. The journal is published quarterly, in March, June, September and December, and welcomes manuscripts on any aspect of diatom biology.
In addition to full-length papers, short notes and reviews of recent literature are published which need not contain all the sections required for full-length papers; we see these as being necessary to record information which is of interest but which cannot be followed up in detail. Discursive “Opinion” papers are encouraged which would not necessarily follow the normal lay-out. If extremely long papers are to be offered, the author(s) should contact the editors first to discuss any problems. Book reviews, obituaries and meeting reports can be published. All papers will be subject to critical review by the editors and referees, as appropriate to their content. Papers will be accepted in English only.
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