{"title":"头孢唑林和头孢唑林-阿奇霉素治疗剖宫产手术部位感染的比较:发展中国家的一项准实验研究","authors":"M. Mosadegh, N. Nouri, M. Ghasemi","doi":"10.5812/iji.119790","DOIUrl":null,"url":null,"abstract":"Background: Prophylactic antibiotics effectively reduce the incidence of infection associated with cesarean section after labor. The use of a first-generation cephalosporin for antibiotic prophylaxis has been suggested in these patients, but in some studies, increasing the spectrum of antibiotic prophylaxis by adding another antibiotic to standard cephalosporin may provide greater protection against post-cesarean wound infections. Objectives: The present study aimed to compare the effects of conventional prophylaxis with cefazolin with a combination of cefazolin and azithromycin in reducing wound infection. Methods: In this quasi-experimental study, 200 cesarean section candidates admitted to Ali Ibn Abi Taleb Hospital in Zahedan, Iran, in 2019 - 2020 were divided into two groups of 100 patients. The control group received cefazolin alone, and the intervention group received cefazolin and azithromycin. Finally, in addition to demographic factors, various underlying diseases, causes of cesarean section, non-infectious wound complications, and post-surgery wound infection were investigated. Results: The two groups were homogenized in terms of age and BMI of patients. Surgical wound infection occurred after cesarean section in 3% of patients in the control group. Only 1% of infections were observed in patients in the intervention group, and the two groups had a statistically significant difference (P = 0.01). Conclusions: Compared with cefazolin alone, the combination of cefazolin and azithromycin was more effective in preventing cesarean section wound infection. Therefore, the combined use of these two antibiotics instead of cefazolin alone is recommended for this desirable clinical outcome.","PeriodicalId":13989,"journal":{"name":"International Journal of Infection","volume":"43 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Comparison of Cesarean Surgical Site Infection in Patients Treated with Cefazolin and Cefazolin-Azithromycin Regimes: A Quasi-experimental Study in a Developing Country\",\"authors\":\"M. Mosadegh, N. Nouri, M. Ghasemi\",\"doi\":\"10.5812/iji.119790\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Prophylactic antibiotics effectively reduce the incidence of infection associated with cesarean section after labor. The use of a first-generation cephalosporin for antibiotic prophylaxis has been suggested in these patients, but in some studies, increasing the spectrum of antibiotic prophylaxis by adding another antibiotic to standard cephalosporin may provide greater protection against post-cesarean wound infections. Objectives: The present study aimed to compare the effects of conventional prophylaxis with cefazolin with a combination of cefazolin and azithromycin in reducing wound infection. Methods: In this quasi-experimental study, 200 cesarean section candidates admitted to Ali Ibn Abi Taleb Hospital in Zahedan, Iran, in 2019 - 2020 were divided into two groups of 100 patients. The control group received cefazolin alone, and the intervention group received cefazolin and azithromycin. Finally, in addition to demographic factors, various underlying diseases, causes of cesarean section, non-infectious wound complications, and post-surgery wound infection were investigated. Results: The two groups were homogenized in terms of age and BMI of patients. Surgical wound infection occurred after cesarean section in 3% of patients in the control group. Only 1% of infections were observed in patients in the intervention group, and the two groups had a statistically significant difference (P = 0.01). Conclusions: Compared with cefazolin alone, the combination of cefazolin and azithromycin was more effective in preventing cesarean section wound infection. Therefore, the combined use of these two antibiotics instead of cefazolin alone is recommended for this desirable clinical outcome.\",\"PeriodicalId\":13989,\"journal\":{\"name\":\"International Journal of Infection\",\"volume\":\"43 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Infection\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5812/iji.119790\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Infection","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5812/iji.119790","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
背景:预防性使用抗生素可有效降低剖宫产术后感染的发生率。已建议在这些患者中使用第一代头孢菌素进行抗生素预防,但在一些研究中,通过在标准头孢菌素中添加另一种抗生素来增加抗生素预防的范围,可能会对剖宫产后伤口感染提供更大的保护。目的:本研究旨在比较头孢唑林常规预防与头孢唑林联合阿奇霉素减少伤口感染的效果。方法:将2019 - 2020年伊朗扎黑丹Ali Ibn Abi Taleb医院收治的200例剖宫产患者分为两组,每组100例。对照组给予头孢唑林单独治疗,干预组给予头孢唑林联合阿奇霉素治疗。最后,除了人口因素外,还调查了各种潜在疾病、剖宫产的原因、非感染性伤口并发症和术后伤口感染。结果:两组患者年龄、BMI均为均匀化。对照组剖宫产术后创面感染发生率为3%。干预组患者感染发生率仅为1%,两组差异有统计学意义(P = 0.01)。结论:与单用头孢唑林相比,头孢唑林联合阿奇霉素预防剖宫产切口感染的效果更好。因此,建议联合使用这两种抗生素,而不是单独使用头孢唑林,以获得理想的临床结果。
Comparison of Cesarean Surgical Site Infection in Patients Treated with Cefazolin and Cefazolin-Azithromycin Regimes: A Quasi-experimental Study in a Developing Country
Background: Prophylactic antibiotics effectively reduce the incidence of infection associated with cesarean section after labor. The use of a first-generation cephalosporin for antibiotic prophylaxis has been suggested in these patients, but in some studies, increasing the spectrum of antibiotic prophylaxis by adding another antibiotic to standard cephalosporin may provide greater protection against post-cesarean wound infections. Objectives: The present study aimed to compare the effects of conventional prophylaxis with cefazolin with a combination of cefazolin and azithromycin in reducing wound infection. Methods: In this quasi-experimental study, 200 cesarean section candidates admitted to Ali Ibn Abi Taleb Hospital in Zahedan, Iran, in 2019 - 2020 were divided into two groups of 100 patients. The control group received cefazolin alone, and the intervention group received cefazolin and azithromycin. Finally, in addition to demographic factors, various underlying diseases, causes of cesarean section, non-infectious wound complications, and post-surgery wound infection were investigated. Results: The two groups were homogenized in terms of age and BMI of patients. Surgical wound infection occurred after cesarean section in 3% of patients in the control group. Only 1% of infections were observed in patients in the intervention group, and the two groups had a statistically significant difference (P = 0.01). Conclusions: Compared with cefazolin alone, the combination of cefazolin and azithromycin was more effective in preventing cesarean section wound infection. Therefore, the combined use of these two antibiotics instead of cefazolin alone is recommended for this desirable clinical outcome.