微量元素锌和硒在新冠肺炎疫情中的意义

Q4 Biochemistry, Genetics and Molecular Biology
M. Gulich, N. L. Yemchenko, V.G. Kaplinenko, O.O. Kharchenko
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引用次数: 0

摘要

在COVID-19大流行持续的情况下,当许多关于预防和治疗策略的问题尚未解决,并且正在寻找最佳抗病毒药物时,应关注微量元素锌和硒在提高人体对病毒感染的抵抗力及其对SARS-CoV-2的直接抗病毒活性中的作用。实验数据表明,微量元素锌和硒不仅通过调节体液免疫和细胞免疫的各个层面的免疫反应,而且在病毒性疾病的辅助治疗中也可以发挥重要作用。这在COVID-19的情况下尤为重要。对这些微量元素的直接抗病毒作用的研究证实了其对SARS-CoV-2的3种主要途径:1 .通过与病毒主要蛋白酶M(Pro)半胱氨酸sh -基团的共价结合来对抗病毒的复制和转录;锌对其RNA聚合酶活性的抑制作用;II -通过阻断其刺突蛋白的蛋白质二硫异构酶(RDI)的sh -基团,阻止病毒渗透到细胞中;III -由于阻断了SARS-CoV-2聚体和血管紧张素转换酶(ACE-2)在超低、非特化氧化态(Zn+1和Se-2)下的静电相互作用,降低了病毒的吸附能力。这些微量元素的抗病毒作用强度可能取决于它们的化学形态。研究发现,纳米技术制备的柠檬酸锌(锌与柠檬酸的五元配合物)和柠檬酸单硒具有更大的作用强度和更高的化学纯度。考虑到锌和硒的免疫刺激和直接抗病毒作用,应考虑将其以药物和膳食补充剂的形式使用,作为SARS-CoV-2患者的辅助治疗,或作为COVID-19传播期间未感染风险人群的预防策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trace Elements Zinc and Selenium: Their Significance in the Conditions of the COVID-19 Pandemic
Within the conditions of the ongoing COVID-19 pandemic, when many questions regarding prevention and treatment strategies remain unsolved and the search for the best antiviral agents is underway, attention should be paid to the role of trace elements zinc and selenium in increasing the body’s resistance to viral infections and their direct antiviral activity against SARS-CoV-2. Experimental data show that trace elements zinc and selenium not only act through regulating the immune response at all levels of humoral and cellular immunity, but also can play a significant role in adjuvant therapy for viral diseases. This is especially relevant in the case of COVID-19. Studies of the direct antiviral effect of these microelements testify to its 3 main ways to SARS-CoV-2: I — counteraction to virus replication and its transcription through: (i) their covalent binding to the SH-group of the cysteine of the main protease M(Pro) of the virus; (ii) inhibition of its RNA polymerase activity by zinc; II — preventing the penetration of the virus into cells due to blocking SH-groups of protein disulfide isomerase (RDI) of the protein of its spikes (peplomers); III — decreasing the adsorption capacity of the virus due to the blocking of the electrostatic interaction of SARS-CoV-2 peplomers and angiotensin-converting enzyme (ACE-2) in ultra-low, uncharacteristic oxidation states (Zn+1 and Se-2). The intensity of the antiviral action of these trace elements may depend on their chemical form. It was found that zinc citrate (a five-membered complex of zinc with citric acid) and monoselenium citric acid obtained with the help of nanotechnology have a greater intensity of action and higher chemical purity. Taking into account the immunostimulating and direct antiviral effect of zinc and selenium, their use in the form of pharmaceuticals and dietary supplements should be considered as adjunctive therapy for SARS-CoV-2 in patients, or as a preventive strategy for uninfected people from risk groups during the spread of COVID-19.
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来源期刊
Mikrobiolohichnyi zhurnal
Mikrobiolohichnyi zhurnal Medicine-Microbiology (medical)
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