聚偏氟乙烯和聚己内酯掺入无定形磷酸钙颗粒的体外生物活性比较评价

Hasnat Zamin, Takeshi Yabutsuka, S. Takai, H. Sakaguchi
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引用次数: 1

摘要

比较研究了聚偏氟乙烯(PVDF)和聚己内酯(PCL)掺入无定形磷酸钙颗粒对模拟体液(SBF)仿生环境中磷灰石形成能力的诱导作用。采用溶剂浇铸法制备了含无定形磷酸钙颗粒的PVDF和PCL薄膜。这些无定形磷酸钙颗粒在诱导磷灰石形成方面非常活跃。结果表明PCL和PVDF均能成功地在SBF中形成磷灰石。然而,我们发现PVDF和PCL在SBF中无定形磷酸钙颗粒的数量和磷灰石形成的诱导期有显著差异。这些类型的生物活性高分子复合材料是有吸引力的候选骨修复材料,具有灵活性和高磷灰石形成能力。(2020年8月28日收稿;接受2020年9月11日)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A COMPARITIVE IN VITRO BIOACTIVY EVALUATION OF POLYVINYLIDENE FLUORIDE AND POLYCAPROLACTONE INCORPORATED WITH AMORPHOUS CALCIUM PHOSPHATE PARTICLES
A comparative study of polyvinylidene fluoride (PVDF) and polycaprolactone (PCL) incorporated with particles of amorphous calcium phosphate on the induction of apatite formation ability in simulated body fluid (SBF)-biomimetic environment has been investigated. PVDF and PCL films containing amorphous calcium phosphate particles were fabricated using the solvent casting method. These amorphous calcium phosphate particles were highly active in inducing apatite formation. Results showed that both PCL and PVDF successfully resulted in apatite formation in SBF. However, it was found that the amount of amorphous calcium phosphate particles and the induction period of the apatite formation in SBF significantly varied for PVDF and PCL. These types of bioactive polymeric composite materials are attractive candidates as bone restorative materials with flexibility as well as high apatite forming ability. (Received Aug 28, 2020; Accepted Sep 11, 2020)
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