{"title":"生物肌动蛋白的抗菌活性","authors":"Humio Osaki , Masato Furuya , Hideyuki Nagasawa , Naoyoshi Suzuki","doi":"10.1016/S0174-3031(84)80010-4","DOIUrl":null,"url":null,"abstract":"<div><p>A newly developed enzyme-hydrolyzed toxoplasma-hyperimmune bovine serum preparation, Obioactin, was examined for its anti-microbial and related actions against heterologous protozoa, bacteria, and viruses both <em>in-vivo</em> and <em>in-vitro</em>.</p><p>An appreciable efficacy of Obioactin in a combination with nifurtimox, Lampit<sup>®</sup> was observed in experimental <em>Trypanosoma cruzi</em> infections in mice. But prophylactic applications of the agent alone or joint with Lampit were in vain in mice.</p><p><em>In-vitro</em> digestion of certain bacteria in mouse peritoneal macrophages was accelerated in the presence of the agent being three to ten times stronger than that in untreated macrophages.</p><p>Inhibitory effect of Obioactin on <em>in-vitro</em> infectivity of viruses was suggested.</p></div>","PeriodicalId":79282,"journal":{"name":"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...","volume":"256 3","pages":"Pages 328-334"},"PeriodicalIF":0.0000,"publicationDate":"1984-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0174-3031(84)80010-4","citationCount":"2","resultStr":"{\"title\":\"Antimicrobial activity of obioactin\",\"authors\":\"Humio Osaki , Masato Furuya , Hideyuki Nagasawa , Naoyoshi Suzuki\",\"doi\":\"10.1016/S0174-3031(84)80010-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A newly developed enzyme-hydrolyzed toxoplasma-hyperimmune bovine serum preparation, Obioactin, was examined for its anti-microbial and related actions against heterologous protozoa, bacteria, and viruses both <em>in-vivo</em> and <em>in-vitro</em>.</p><p>An appreciable efficacy of Obioactin in a combination with nifurtimox, Lampit<sup>®</sup> was observed in experimental <em>Trypanosoma cruzi</em> infections in mice. But prophylactic applications of the agent alone or joint with Lampit were in vain in mice.</p><p><em>In-vitro</em> digestion of certain bacteria in mouse peritoneal macrophages was accelerated in the presence of the agent being three to ten times stronger than that in untreated macrophages.</p><p>Inhibitory effect of Obioactin on <em>in-vitro</em> infectivity of viruses was suggested.</p></div>\",\"PeriodicalId\":79282,\"journal\":{\"name\":\"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...\",\"volume\":\"256 3\",\"pages\":\"Pages 328-334\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0174-3031(84)80010-4\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0174303184800104\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0174303184800104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A newly developed enzyme-hydrolyzed toxoplasma-hyperimmune bovine serum preparation, Obioactin, was examined for its anti-microbial and related actions against heterologous protozoa, bacteria, and viruses both in-vivo and in-vitro.
An appreciable efficacy of Obioactin in a combination with nifurtimox, Lampit® was observed in experimental Trypanosoma cruzi infections in mice. But prophylactic applications of the agent alone or joint with Lampit were in vain in mice.
In-vitro digestion of certain bacteria in mouse peritoneal macrophages was accelerated in the presence of the agent being three to ten times stronger than that in untreated macrophages.
Inhibitory effect of Obioactin on in-vitro infectivity of viruses was suggested.
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