金缕草、苦参和甲状腺素对甲状腺功能减退模型小鼠甲状腺功能的影响

Tehreem Zulfiqar
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Aims & Objectives: So the present study is designed to\nexplore the effects of Ethanolic extract of Commiphora mukul (CMEE) and Withania somnifera (WSEE) on\nT3, T4 and TSH levels keeping thyroxine as a gold standard in murine model of hypothyroidism. Place and\nduration of study: This study was carried out in the animal house of PGMI, Lahore. Total duration of study\nwas 38 days. Material & Methods: 50 female rats were divided into 5 groups. G-1 the control group. G-2\nreceived methimazole 60mg/kg/day for 21 days in order to induce hypothyroidism and left untreated for self\nrecovery & G3-5 were induced with methimazole in the same way. After induction all the groups were treated\nfor 15 days, G-3: CMEE 0.2g/kg/day orally, G4: WSEE 1.4g/kg/day orally and G-5 received the gold\nstandard Thyroxin 0.6μg/100gm BW S/C. 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引用次数: 0

摘要

导读:由于不健康的生活方式和营养缺乏,甲状腺疾病,特别是甲状腺功能减退症呈上升趋势,这需要对这一领域进行研究。迄今为止,单药治疗甲状腺素被认为是主要的治疗方法,但除了在使甲状腺激素水平正常化方面有有益的作用外,它对心脏有严重的影响,因此需要寻找更安全的自然疗法。黄皮草和大黄草被认为是两种对T3和t4水平有有益调节作用的植物。然而,考虑到TSH的诊断重要性,这些植物提取物对TSH水平的影响需要确定。目的与目的:本研究旨在探讨金针藤(CMEE)和龙茅(WSEE)乙醇提取物对甲状腺素(onT3、T4和TSH)水平的影响,并以甲状腺素为金标准对甲状腺功能减退模型小鼠的影响。研究地点和时间:本研究在拉合尔PGMI动物舍进行。研究总持续时间为38天。材料与方法:50只雌性大鼠分为5组。G-1为对照组。g -2组给予甲巯咪唑60mg/kg/天,连续21天诱导甲状腺功能减退,不治疗自行恢复;G3-5组同样给予甲巯咪唑诱导。诱导后各组均给予15 d治疗,G-3组:CMEE 0.2g/kg/d口服,G4组:WSEE 1.4g/kg/d口服,G-5组给予金标准甲状腺素0.6 g/100gm BW S/C。各组患者于第1天进行甲状腺功能检测,甲巯咪唑给药后第22天和治疗结束后第38天重复检测。结果:CMEE和WSEE均能显著纠正T3、T4水平。CMEE对T3水平的影响更大,而WSEE对T4水平的纠正作用更大。TSH水平也恢复正常,这表明这两种提取物除了能纠正T3和T4水平外,还能纠正TSH。结论:临床应用黄芪提取物治疗甲状腺功能减退,对纠正甲状腺功能(T3、T4、TSH)有显著作用。然而,临床研究是强烈建议在这个领域。关键词:金缕草,苦参,甲状腺功能减退,甲状腺素
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Commiphora mukul, Withania somnifera and Thyroxine on Thyroid Profile in Murine Model of Hypothyroidism
Introduction: Thyroid disorders, especially hypothyroidism are on the rise these days due to unhealthy lifestyle and nutritional deficiencies which calls for research in this domain. Monotherapy with thyroxine is considered the main line of treatment up till now but besides its beneficial role in normalizing thyroid hormone levels, it has serious cardiac effects which leads to the search of safer natural remedies. Commiphora mukul and Withanias omnifera are considered two such plants with beneficial role in correcting T3 and T4 levels respectively. However keeping in mind the diagnostic importance of TSH, the effects of these phyto extracts on TSH levels needs to be established. Aims & Objectives: So the present study is designed to explore the effects of Ethanolic extract of Commiphora mukul (CMEE) and Withania somnifera (WSEE) on T3, T4 and TSH levels keeping thyroxine as a gold standard in murine model of hypothyroidism. Place and duration of study: This study was carried out in the animal house of PGMI, Lahore. Total duration of study was 38 days. Material & Methods: 50 female rats were divided into 5 groups. G-1 the control group. G-2 received methimazole 60mg/kg/day for 21 days in order to induce hypothyroidism and left untreated for self recovery & G3-5 were induced with methimazole in the same way. After induction all the groups were treated for 15 days, G-3: CMEE 0.2g/kg/day orally, G4: WSEE 1.4g/kg/day orally and G-5 received the gold standard Thyroxin 0.6μg/100gm BW S/C. Thyroid function tests were performed in all groups on Day 1, repeated on Day 22 after methimazole administration and on Day 38 following completion of treatment. Results: The results showed that both CMEE and WSEE corrected T3 and T4 levels to significant extent. CMEE had more effect on T3 levels whereas WSEE corrected T4 levels more. TSH levels were also reverted to normal showing the potential of both these extracts to correct TSH besides T3, T4 levels. Conclusion: This proves that these extracts may play a significant role in correcting thyroid profile (T3, T4 & TSH) if used clinically for the treatment of hypothyroidism. However, clinical research is highly recommended in this domain. Key words: Commiphora mukul, Withania somnifera, hypothyroidism, thyroxine.
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