持续有氧运动对冠状动脉疾病大鼠急性心肌梗死诱导模型血清血管生成和血管抑制因子的影响

E. Dehghan, A. Ravasi, R. Nouri, A. Gaeini, M. Nekooei, M. Delavari, Masoud Khorsandi Kolur
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摘要

背景。有氧训练在一定程度上纠正冠状动脉疾病(CAD)患者的内皮功能障碍,但最有效的运动形式尚不清楚;因此,本研究的目的是研究连续8周有氧运动对冠状动脉疾病雄性大鼠血清血管内皮生长因子(VEGF)和血管内皮抑制素(ES)的影响。方法。本实验以30只2月龄健康雄性Wistar大鼠为研究对象,分为实验组、冠心病对照组和健康对照组。在用异丙肾上腺素使20只大鼠破裂后,实验组中的10只大鼠在跑步机上进行了8周的连续有氧运动,强度从第一阶段的50%增加到最后阶段的78%,而两个对照组都没有运动。最后一次训练72小时后,采血检测血清VEGF和ES指数,采用单因素方差分析和Scheffer posthoc检验比较各组变量的平均值。结果。结果表明,间断有氧运动可使冠心病大鼠血液中VEGF升高(P≤0.01),而实验组内皮抑素水平与对照组比较差异无统计学意义(P>0.05)。结论。看来,持续有氧运动可以用于冠心病患者的康复,并可能在血管生成过程中有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of continuous aerobic exercise on serum angiogenic and angiostatic factors in induction model of acute myocardial infarction male rats with coronary artery disease
Background. Aerobic training somewhat corrects endothelial dysfunction in patients with coronary artery disease (CAD), but the most effective form of exercise is still unclear; therefore, the purpose of the present study was to investigate the effect of 8 weeks of continuous aerobic exercise on serum vascular endothelial growth factor (VEGF) as an angiogenic factor and endostatin (ES) as an angiostatic factor in male rats with coronary artery disease. Methods. The subjects of the present experimental study were 30 healthy male 2-months old Wistar rats divided into three groups: the experimental group, the control group with coronary artery disease, and the healthy control group. After rupturing 20 of the rats by isoproterenol, 10 rats in the experimental group performed eight weeks of continuous aerobic exercise on a treadmill, with an incremental intensity of 50% in the first session to 78% in the last session, whereas both control groups did not exercise. Seventy-two hours after the final training session, blood samples were taken for serum VEGF and ES indices, and one-way ANOVA with Scheffer posthoc tests was used to compare the mean of variables among the studied groups. Results. The results showed that discontinuous aerobic exercise could increase the blood VEGF in rats with coronary artery disease (P≤0.01), while there was no difference in the level of endostatin in the experimental group compared with control groups (P>0.05). Conclusion. It seems that continuous aerobic exercises can be used in the rehabilitation of patients with coronary artery disease and might be effective in the process of angiogenesis.
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